Motion in tRNA [trna]

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Classification Known RNA Motion [N-R-2]

1ASY w/ synthaseConformation 3 [ PartsList ]
1ASZ w/ synthase and ATPConformation 4 [ PartsList ]
2TRA Asp tRNA (A form)Conformation 1
3TRA Asp tRNA (B form)Conformation 2

Moras and co-workers have solved the structures of yeast tRNA(Asp) from yeast, both in its free state and complexed with its tRNA-synthetase. The molecule preserves its fundamental 'L' shape but nevertheless undergoes important conformational changes. The two arms of the 'L' bend, which brings the 3' acceptor end and the anticodon loop closer together. The motion is completed by a substantial change in the anticodon loop, placing the anticodon bases in a more exposed position, enabling their interaction with the synthetase.

Particular values describing motion
Creation Date = 1998-06-29 12:32:40.000
Experimental Methods = x (Traditional X-ray)
Modification Date = 1998-06-30 14:43:34.000

B Rees, J Cavarelli, D Moras (1996). Conformational flexibility of tRNA: structural changes in yeast tRNA(Asp) upon binding to aspartyl-tRNA synthetase. Biochimie 78(7):624-631 [Medline info for 97114086]

GO terms associated with structures
Molecular functionnucleic acid binding, tRNA ligase activity, aspartate-tRNA ligase activity, ATP binding
Cellular componentcytoplasm
Biological processtRNA aminoacylation for protein translation, aspartyl-tRNA aminoacylation


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Best representative
Morph Morph name Structure #1 Structure #2 Residues
tRNA 2TRA [ ] 3TRA [ ] 72

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_