Motion in tRNA [trna]
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Classification Known RNA Motion [N-R-2]
Structures 1ASY w/ synthaseConformation 3 [ PartsList ] 1ASZ w/ synthase and ATPConformation 4 [ PartsList ] 2TRA Asp tRNA (A form)Conformation 1 3TRA Asp tRNA (B form)Conformation 2
Description Moras and co-workers have solved the structures of yeast tRNA(Asp) from yeast, both in its free state and complexed with its tRNA-synthetase. The molecule preserves its fundamental 'L' shape but nevertheless undergoes important conformational changes. The two arms of the 'L' bend, which brings the 3' acceptor end and the anticodon loop closer together. The motion is completed by a substantial change in the anticodon loop, placing the anticodon bases in a more exposed position, enabling their interaction with the synthetase.
Particular values describing motion Creation Date = 1998-06-29 12:32:40.000 Experimental Methods = x (Traditional X-ray) Modification Date = 1998-06-30 14:43:34.000
References B Rees, J Cavarelli, D Moras (1996). Conformational flexibility of tRNA: structural changes in yeast tRNA(Asp) upon binding to aspartyl-tRNA synthetase. Biochimie 78(7):624-631 [Medline info for 97114086]
GO terms associated with structures Molecular function aspartate-tRNA ligase activity, ATP binding, nucleic acid binding, tRNA ligase activity Cellular component cytoplasm Biological process aspartyl-tRNA aminoacylation, tRNA aminoacylation for protein translation
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu