Motion in Topoisomerase [topo]

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Classification Suspected Domain Motion, Unclassifiable Mechanism [D-?-2]

1ECL Topoisomerase I [ PartsList ]
1D6M Topoisomerase III
1I7D Topoisomerase III w/ DNA

Motion detected in Type IA DNA topoisomerases from E. coli. Comparison of crystal structures of topoisomerase III shows large rotating movement of DNA-binding domain.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

C D Lima, J C Wang and A Mondragon (1994). Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature. 367: 138-146. [Medline info for 94159070]
: Mondragon A, DiGate R. (1999). The structure of Escherichia coli DNA topoisomerase III. Structure Fold Des 7:1373-83. [Medline info for 10574789]
Changela A, DiGate RJ, Mondragon A. (2001) Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule. Nature 411:1077-81. [Medline info for 11429611]

GO terms associated with structures
Molecular functionnucleic acid binding, DNA binding, DNA topoisomerase activity, DNA topoisomerase type I activity
Cellular componentchromosome
Biological processDNA topological change, DNA unwinding, DNA modification


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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Topoisomerase III 1d6m [ A ] 1i7d [ A ] 620

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_