Motion in Topoisomerase [topo]

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Classification Suspected Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1ECL Topoisomerase I [ PartsList ] 1D6M Topoisomerase III 1I7D Topoisomerase III w/ DNA

Description Motion detected in Type IA DNA topoisomerases from E. coli. Comparison of crystal structures of topoisomerase III shows large rotating movement of DNA-binding domain.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References C D Lima, J C Wang and A Mondragon (1994). Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature. 367: 138-146. [Medline info for 94159070] : Mondragon A, DiGate R. (1999). The structure of Escherichia coli DNA topoisomerase III. Structure Fold Des 7:1373-83. [Medline info for 10574789] Changela A, DiGate RJ, Mondragon A. (2001) Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule. Nature 411:1077-81. [Medline info for 11429611]

GO terms associated with structures Molecular function DNA topoisomerase activity, DNA topoisomerase type I activity, nucleic acid binding, DNA binding Cellular component chromosome Biological process DNA unwinding, DNA modification, DNA topological change

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu