Motion in TATA-box Binding Protein (TBP) [tbp]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

1TBP Conformation 1 [ PartsList ]

Twisting of a central sheet moves 2 domains ~10 degrees. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

A Klug (1993). Opening the gateway. Nat. 365:486 [Medline info for 94157914]
J L Kim, D B Nikolov and S K Burley (1993). Co-crystal structure of TBP recognizing the minor groove a TATA element. Nature. 365: 520-527. [Medline info for 94157914]
Y Kim, J H Geiger, S Hahn and P B Sigler (1993). Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-520. [Medline info for 94157914]
D I Chasman, K M Flaherty, P A Sharp and R D Kornberg (1993). Crystal Structure of Yeast TATA-Binding Protein and Model for Interaction with DNA. Proc. Natl. Acad. Sci. 90: 8174-8178. [Medline info for 93376766]

GO terms associated with structures
Molecular functionRNA polymerase II transcription factor activity, binding, DNA binding
Cellular componentnucleus, transcription factor TFIID complex
Biological processtranscription initiation from RNA polymerase II promoter, regulation of transcription, DNA-dependent


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Best representative
Morph Morph name Structure #1 Structure #2 Residues
TATA-binding protein upload [ A ] upload [ B ] 180

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1tbaB-1ytbB Transcription Initiation Facto 1tba [ B ] 1ytb [ B ] 180
va1tbaB-1ytbA Transcription Initiation Facto 1tba [ B ] 1ytb [ A ] 180
va1tbaB-1ytfA Transcription Initiation Facto 1tba [ B ] 1ytf [ A ] 180

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Email: Mark.Gerstein _at_