Motion in TATA-box Binding Protein (TBP) [tbp]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

1TBP Conformation 1 [ PartsList ]

Twisting of a central sheet moves 2 domains ~10 degrees. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

A Klug (1993). Opening the gateway. Nat. 365:486 [Medline info for 94157914]
J L Kim, D B Nikolov and S K Burley (1993). Co-crystal structure of TBP recognizing the minor groove a TATA element. Nature. 365: 520-527. [Medline info for 94157914]
Y Kim, J H Geiger, S Hahn and P B Sigler (1993). Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-520. [Medline info for 94157914]
D I Chasman, K M Flaherty, P A Sharp and R D Kornberg (1993). Crystal Structure of Yeast TATA-Binding Protein and Model for Interaction with DNA. Proc. Natl. Acad. Sci. 90: 8174-8178. [Medline info for 93376766]

GO terms associated with structures
Molecular functionDNA binding, RNA polymerase II transcription factor activity, binding
Cellular componentnucleus, transcription factor TFIID complex
Biological processregulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter


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Best representative
Morph Morph name Structure #1 Structure #2 Residues
TATA-binding protein upload [ A ] upload [ B ] 180

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1tbaB-1ytbB Transcription Initiation Facto 1tba [ B ] 1ytb [ B ] 180
va1tbaB-1ytbA Transcription Initiation Facto 1tba [ B ] 1ytb [ A ] 180
va1tbaB-1ytfA Transcription Initiation Facto 1tba [ B ] 1ytf [ A ] 180

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Email: Mark.Gerstein _at_