Motion in TATA-box Binding Protein (TBP) [tbp]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1TBP Conformation 1 [ PartsList ]

Description Twisting of a central sheet moves 2 domains ~10 degrees. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References A Klug (1993). Opening the gateway. Nat. 365:486 [Medline info for 94157914] J L Kim, D B Nikolov and S K Burley (1993). Co-crystal structure of TBP recognizing the minor groove a TATA element. Nature. 365: 520-527. [Medline info for 94157914] Y Kim, J H Geiger, S Hahn and P B Sigler (1993). Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-520. [Medline info for 94157914] D I Chasman, K M Flaherty, P A Sharp and R D Kornberg (1993). Crystal Structure of Yeast TATA-Binding Protein and Model for Interaction with DNA. Proc. Natl. Acad. Sci. 90: 8174-8178. [Medline info for 93376766]

GO terms associated with structures Molecular function DNA binding, RNA polymerase II transcription factor activity, binding Cellular component transcription factor TFIID complex, nucleus Biological process regulation of transcription, DNA-dependent, transcription initiation from RNA polymerase II promoter

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues TATA-binding protein upload [ A ] upload [ B ] 180

Automatic morphs Morph Morph name Structure #1 Structure #2 Residues va1tbaB-1ytbB Transcription Initiation Facto 1tba [ B ] 1ytb [ B ] 180 va1tbaB-1ytbA Transcription Initiation Facto 1tba [ B ] 1ytb [ A ] 180 va1tbaB-1ytfA Transcription Initiation Facto 1tba [ B ] 1ytf [ A ] 180

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu