Motion in TATA-box Binding Protein (TBP) [tbp]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1TBP Conformation 1 [ PartsList ]

Description Twisting of a central sheet moves 2 domains ~10 degrees. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References A Klug (1993). Opening the gateway. Nat. 365:486 [Medline info for 94157914] J L Kim, D B Nikolov and S K Burley (1993). Co-crystal structure of TBP recognizing the minor groove a TATA element. Nature. 365: 520-527. [Medline info for 94157914] Y Kim, J H Geiger, S Hahn and P B Sigler (1993). Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-520. [Medline info for 94157914] D I Chasman, K M Flaherty, P A Sharp and R D Kornberg (1993). Crystal Structure of Yeast TATA-Binding Protein and Model for Interaction with DNA. Proc. Natl. Acad. Sci. 90: 8174-8178. [Medline info for 93376766]

GO terms associated with structures Molecular function binding, DNA binding, RNA polymerase II transcription factor activity Cellular component nucleus, transcription factor TFIID complex Biological process transcription initiation from RNA polymerase II promoter, regulation of transcription, DNA-dependent

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu