Motion in NF-kappa B [nfkb]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1NFK Conformation 2 [ PartsList ] 1SVC Conformation 1 [ PartsList ]

Description Comparison of two crystal conformations shows differences.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References Ghosh G, van Duyne G, Ghosh S, Sigler PB. (1995) Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature 373:303-10. [Medline info for 95132005] Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC. (1995) Structure of the NF-kappa B p50 homodimer bound to DNA. Nature 373:311-7. [Medline info for 95132006]

GO terms associated with structures Molecular function transcription factor activity, protein binding Cellular component nucleus Biological process signal transduction, regulation of transcription, regulation of transcription, DNA-dependent

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues NFkB upload [ A ] upload [ P ] 311

Automatic morphs Morph Morph name Structure #1 Structure #2 Residues va1vkxA-1ramB Nf-Kappa-B P65 1vkx [ A ] 1ram [ B ] 273 va2ramB-1vkxA Transcription Factor Nf-Kb P65 2ram [ B ] 1vkx [ A ] 273 va2ramB-1ramA Transcription Factor Nf-Kb P65 2ram [ B ] 1ram [ A ] 273 va2ramA-1ramB Transcription Factor Nf-Kb P65 2ram [ A ] 1ram [ B ] 273

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu