Motion in Cell Adhesion Molecule CD2 [cd2]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures
1HNF Conformation 1 [ PartsList ]
1HNG Conformation 2 [ PartsList ]

Description
1 interdomain linkage, 1 hinge, 20 degree rotation. Comparison of rat and human forms reveals rotation between two Ig-like domain.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
M J Bennet, M P Schlunegger, and D Eisenberg (1995). 3D Domain swapping: A Mechanism for oligomer assembly. Prot. Sci 4:2455-2468. [Medline info for 93250020]
E Y Jones, S J Davis, A F Williams, K Harlos and D I Stuart (1992). Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2. Nature. 360: 232-239. [Medline info for 93063364]
D L Bodian, E Y Jones, K Harlos, D I Stuart and S J Davis (1994). Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution. Structure. 2: 755-766. [Medline info for 95086863]

GO terms associated with structures
Cellular componentintegral to membrane
Biological processcell adhesion

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
CD2 (outlier) 1hnf [ A ] 1hng [ A ] 176



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu