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Conformational changes associated with protein-protein interactions
Supplementary material for Goh, Milburn & Gerstein, 2004
Protein Name |
Binding Ligand |
Conformation 1 | Conformation 2 | Max. C alpha Displacement (A) | Max. θ Change | Classification |
Discussed |
Myosin |
Actin |
n/a | n/a | 9* | 21* | Induced |
Yes |
Antibody Spe7
|
Trx-Shear3 |
n/a | n/a | 6.7* | 90* | Equilibrium |
Yes |
GpIb-IX-V
|
Thrombin |
1P8V | 1OOK | 37* | 90* | Equilibrium |
Yes |
Gαi Subunit
|
RGS14 |
1BOF | 1KJY | 10.2 | 177 | Induced |
Yes |
FliS
|
FliC |
1ORJ | 1ORY | 29.3 | 168.8 | Induced |
Yes |
| NtrC
|
P |
1DC7 | 1DC8 | 12 | 177 | Equilibrium |
Yes |
FcαR1
|
Fc |
1OVZ | 1OWO | 11 | 180 | Induced |
|
F1-ATPase
|
IF1 |
1BMF | 1OHH | 4.5* | 8.7* | Induced |
|
| Her2
|
Herceptin Fab |
1N8Y | 1N8Z | 13.7 | 170 | Induced |
|
Erythropoietin
|
Erythropoietin Receptor |
1BUY | 1EER | 15.4 | 149.5 | Induced |
|
Antibody D1.3
|
Lysozyme |
1VFA | 1VFB | 15.8 | 0.9 | Lock and Key |
|
GroEL
|
GroES |
1AON | 1OEL | 48.5 | 169.6 | Allosteric |
|
Calmodulin
|
Calmodulin-binding Domain of Skeletal Light Chain Myosin Kinase |
4CLN | 2BBM | 179 | 61 | Allosteric |
|
Proto-oncogene Cbl
|
ZAP-70 Kinase |
2CBL | 1B47 | 7 | 58 | Induced |
|
CDK2
|
cyclinA |
1FIN | 1HCK | 20 | 176 | Induced |
|
Mms2
|
Ubc13 |
1J74 | 1J7D | 20.7 | 164 | Induced |
|
PPARγ
|
Steroid Receptor CoActvator-1 |
1PRG | 1FM6 | 13 | 169 | Equilibrium |
|
TRAF6
|
RANK |
1LB4 | 1LB5 | 16.6 | 133 | Either |
|
XRCC4 |
DNA-Ligase IV |
1FU1 | 1IK9 | 14 | 119 | Induced |
|
RAN
|
RAN-binding protein 2 |
1BYU | 1RRP | 53.4 | 179 | Induced |
|
CheY
|
CheA |
3CHY | 1EAY | 3.8 | 23 | Induced |
* This data was taken from the literature
The stated classifications are assumed based on the experimental data available
