Motion in Xrcc4 [xrcc4]
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Classification [S-n-2]
Structures 1IK9 1FU1
Description Monomer motion of one helical tail of Xrcc4 dimer when in complex with DNA Ligase IV. Helical tails form a coiled coil that unwinds upon ligase binding, leading to a flat interaction surface.
References M S Junop, M Modesti, A Guarné, R Ghirlando, M Gellert, W Yang (2000). Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J, 19:5962-70 [Medline info for 11080143] B L Sibanda, S E Critchlow, J Begun, X Y Pei, S P Jackson, T L Blundell, L Pellegrini (2001). Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol, 8:1015-9 [Medline info for 11702069]
GO terms associated with structures Molecular function DNA ligase (ATP) activity, ATP binding Cellular component nucleus, intracellular Biological process DNA replication, DNA recombination, DNA repair
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu