Motion in Xrcc4 [xrcc4]

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Classification [S-n-2]

Structures
1IK9
1FU1

Description
Monomer motion of one helical tail of Xrcc4 dimer when in complex with DNA Ligase IV. Helical tails form a coiled coil that unwinds upon ligase binding, leading to a flat interaction surface.

References
M S Junop, M Modesti, A Guarné, R Ghirlando, M Gellert, W Yang (2000). Crystal structure of the Xrcc4 DNA repair protein and implications for end joining. EMBO J, 19:5962-70 [Medline info for 11080143]
B L Sibanda, S E Critchlow, J Begun, X Y Pei, S P Jackson, T L Blundell, L Pellegrini (2001). Crystal structure of an Xrcc4-DNA ligase IV complex. Nat Struct Biol, 8:1015-9 [Medline info for 11702069]

GO terms associated with structures
Molecular functionDNA ligase (ATP) activity, ATP binding
Cellular componentnucleus, intracellular
Biological processDNA replication, DNA recombination, DNA repair

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu