Motion in Troponin-C [tropc]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures
1NCX Conformation 1 [ PartsList ]
1NCY Conformation 3 [ PartsList ]
1TNW Conformation 2 [ PartsList ]

Description
The calcium-binding induced conformational change of Troponin-C induces contraction in muscle cells. A single amino acid, Glu41, is responsible the conformational change, through electrostatic interactions with newly bound calcium atoms in a neighboring helix. Mutant proteins lacking this amino acid do not change conformation upon Ca-binding.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

References
R F Service (1996) Flexing Muscle with Just One Amino Acid. Sci. 271:31. [Medline info for 94174274]

GO terms associated with structures
Molecular functioncalcium ion binding

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
N Domain, Troponin C upload [ A ] upload [ A ] 81

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
15439-7452 troponin 1ncx [ A ] 1ncy [ A ] 162
75961-7872 Troponin 1tnp [ A ] 1tnq [ A ] 90
826868-28064 Troponin 5tnc [ A ] 1tnx [ A ] 162
831450-29533 Troponin 5tnc [ A ] 2tn4 [ A ] 159
01631-24090 Troponin C 1tnp [ A ] 1tnq [ A ] 90
01852-24799 Troponin C 1tnp [ A ] 1tnq [ A ] 90
33174-22895 Troponin C upload [ ] upload [ ] 81
36303-20001 Troponin C upload [ ] upload [ ] 81
37110-20331 Troponin C upload [ ] upload [ ] 81
64888-26218 Troponin C upload [ ] upload [ ] 81
73733-24534 Troponin C upload [ ] upload [ ] 81
93600-16886 Troponin C upload [ ] upload [ ] 81
632338-7727 troponin c 1avs [ A ] 1zac [ A ] 90
321284-5674 troponin c 5tnc [ A ] 1tnx [ A ] 162
633932-8975 troponin c 5tnc [ A ] 1tnx [ A ] 162
392695-16090 troponin c 5tnc [ A ] 1tnx [ A ] 162
808810-29366 Troponin C 1ncx [ A ] 1tnw [ A ] 162
392067-14325 troponin c 5tnc [ A ] 1tnx [ A ] 162
558809-20159 troponin c 1zac [ A ] 1avs [ A ] 90
547961-11810 TROPONIN C 1zac [ A ] 1avs [ A ] 90
545504-10787 troponin c 1avs [ A ] 1zac [ A ] 90
568681-22757 troponin c 1zac [ A ] 1avs [ A ] 90
321118-5419 troponin c 5tnc [ A ] 1tnx [ A ] 162
549751-14331 troponin c 1zac [ A ] 1avs [ A ] 90
750297-22907 Troponin C 1spy [ A ] 1ap4 [ A ] 89
752519-23803 Troponin C 1ncx [ A ] 1tn4 [ A ] 159
026820-17263 Troponin C 1a2x [ A ] 1tn4 [ A ] 159
808999-29805 Troponin C 16 frames 1ncx [ A ] 1tnw [ A ] 162
809150-30548 Troponin C 24 frames 1ncx [ A ] 1tnw [ A ] 162
819343-27232 Troponin-C 1ncx [ A ] 1tnx [ A ] 162
819922-27903 Troponin-C 1ncx [ A ] 1ncy [ A ] 162
820348-29303 Troponin-C 1ncx [ A ] 1ncy [ A ] 162
820447-29926 Troponin-C 1ncx [ A ] 1tnx [ A ] 162

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1ap4A-1mxlC Cardiac N-Troponin C 1ap4 [ A ] 1mxl [ C ] 89
va1ap4A-1spyA Cardiac N-Troponin C 1ap4 [ A ] 1spy [ A ] 89
va1blqA-1ncxA N-Troponin C 1blq [ A ] 1ncx [ A ] 162
va1blqA-1ncyA N-Troponin C 1blq [ A ] 1ncy [ A ] 162
va1blqA-1nczA N-Troponin C 1blq [ A ] 1ncz [ A ] 162
va3ctnA-1fi5A Troponin C 3ctn [ A ] 1fi5 [ A ] 81
va1tnwA-1topA Troponin C 1tnw [ A ] 1top [ A ] 162
va1tnwA-1ncxA Troponin C 1tnw [ A ] 1ncx [ A ] 162
va1tnwA-1ncyA Troponin C 1tnw [ A ] 1ncy [ A ] 162
va1tnwA-1nczA Troponin C 1tnw [ A ] 1ncz [ A ] 162
va1tnwA-1zacA Troponin C 1tnw [ A ] 1zac [ A ] 90
va1mxlC-1spyA Troponin C 1mxl [ C ] 1spy [ A ] 89
va1tnwA-1blqA Troponin C 1tnw [ A ] 1blq [ A ] 90
va1ncyA-1zacA Troponin C 1ncy [ A ] 1zac [ A ] 90
va1nczA-1zacA Troponin C 1ncz [ A ] 1zac [ A ] 90
va1ncxA-1zacA Troponin C 1ncx [ A ] 1zac [ A ] 90
va1topA-1blqA Troponin C - Chain _ 1top [ A ] 1blq [ A ] 90
va1topA-1zacA Troponin C - Chain _ 1top [ A ] 1zac [ A ] 90
va1zacA-1tnqA Troponin-C 1zac [ A ] 1tnq [ A ] 90
va1sktA-1blqA Troponin-C 1skt [ A ] 1blq [ A ] 90
va1tnqA-1sktA Troponin-C 1tnq [ A ] 1skt [ A ] 90
va1tnqA-1nczA Troponin-C 1tnq [ A ] 1ncz [ A ] 162
va1tnqA-1ncyA Troponin-C 1tnq [ A ] 1ncy [ A ] 162
va1tnqA-1ncxA Troponin-C 1tnq [ A ] 1ncx [ A ] 162
va1tnqA-1topA Troponin-C 1tnq [ A ] 1top [ A ] 162
va1tnqA-1tnpA Troponin-C 1tnq [ A ] 1tnp [ A ] 90
va1sktA-1tnwA Troponin-C 1skt [ A ] 1tnw [ A ] 162
va1zacA-1blqA Troponin-C 1zac [ A ] 1blq [ A ] 90
va1zacA-1tnpA Troponin-C 1zac [ A ] 1tnp [ A ] 90
va1tnqA-1blqA Troponin-C 1tnq [ A ] 1blq [ A ] 90
va1tnqA-1tnwA Troponin-C 1tnq [ A ] 1tnw [ A ] 162
va1sktA-1topA Troponin-C 1skt [ A ] 1top [ A ] 162
va1sktA-1ncyA Troponin-C 1skt [ A ] 1ncy [ A ] 162
va1sktA-1ncxA Troponin-C 1skt [ A ] 1ncx [ A ] 162
va1sktA-1nczA Troponin-C 1skt [ A ] 1ncz [ A ] 162
va1tnpA-1blqA Troponin-C (Apo) 1tnp [ A ] 1blq [ A ] 90
va1tnpA-1tnwA Troponin-C (Apo) 1tnp [ A ] 1tnw [ A ] 162
va1tnpA-1sktA Troponin-C (Apo) 1tnp [ A ] 1skt [ A ] 90
va1tnpA-1topA Troponin-C (Apo) 1tnp [ A ] 1top [ A ] 162
va1tnpA-1nczA Troponin-C (Apo) 1tnp [ A ] 1ncz [ A ] 162
va1tnpA-1ncxA Troponin-C (Apo) 1tnp [ A ] 1ncx [ A ] 162
va1tnpA-1ncyA Troponin-C (Apo) 1tnp [ A ] 1ncy [ A ] 162

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu