Motion in Troponin-C [tropc]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures 1NCX Conformation 1 [ PartsList ] 1NCY Conformation 3 [ PartsList ] 1TNW Conformation 2 [ PartsList ]

Description The calcium-binding induced conformational change of Troponin-C induces contraction in muscle cells. A single amino acid, Glu41, is responsible the conformational change, through electrostatic interactions with newly bound calcium atoms in a neighboring helix. Mutant proteins lacking this amino acid do not change conformation upon Ca-binding.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References R F Service (1996) Flexing Muscle with Just One Amino Acid. Sci. 271:31. [Medline info for 94174274]

GO terms associated with structures Molecular function calcium ion binding

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu