Motion in Tnf receptor-associated factor 6 (Traf6) [traf6]

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Classification [F-?-2]

Structures
1LB4 Apo form
1LB5 Rank-bound
1LB6 CD40-bound

Description
Changes in conformation of several unstructured regions upon binding of CD40 or NFkB receptor activator.

References
Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H (2002). Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418:443-7. [Medline info for 12140561]

GO terms associated with structures
Molecular functionreceptor activity, transmembrane receptor activity, ubiquitin-protein ligase activity, zinc ion binding
Cellular componentmembrane, ubiquitin ligase complex
Biological processprotein ubiquitination, signal transduction, apoptosis, immune response

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Traf6 1lb4 [ A ] 1lb5 [ A ] 160



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu