Motion in Tnf receptor-associated factor 6 (Traf6) [traf6]

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Classification [F-?-2]

Structures 1LB4 Apo form 1LB5 Rank-bound 1LB6 CD40-bound

Description Changes in conformation of several unstructured regions upon binding of CD40 or NFkB receptor activator.

References Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H (2002). Distinct molecular mechanism for initiating TRAF6 signalling. Nature 418:443-7. [Medline info for 12140561]

GO terms associated with structures Molecular function receptor activity, transmembrane receptor activity, ubiquitin-protein ligase activity, zinc ion binding Cellular component membrane, ubiquitin ligase complex Biological process protein ubiquitination, signal transduction, apoptosis, immune response

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues Traf6 1lb4 [ A ] 1lb5 [ A ] 160

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu