Motion in Topoisomerase type II [topoII]

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Classification [C----]

Structures
1BGW [ PartsList ]
1BJT

Description
Different crystal forms exhibit significant changes in overall architecture, including an extremely large (170°) domain rotation.

References
J M Berger, S J Gamblin, S C Harrison, J C Wang (1996). Structure and mechanism of DNA topoisomerase II. Nature, 379:225-32 [Medline info for 8538787]
D Fass, C E Bogden, J M Berger (1999). Quaternary changes in topoisomerase II may direct orthogonal movement of two DNA strands. Nat Struct Biol, 6:322-6 [Medline info for 10201398]

GO terms associated with structures
Molecular functionDNA binding, DNA topoisomerase (ATP-hydrolyzing) activity, ATP binding
Biological processDNA metabolism, DNA topological change

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Topoisomerase II 1bgw [ A ] 1bjt [ A ] 679

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
577100-15574 t2 upload [ A ] upload [ A ] 679
287036-19503 topoisomerase II upload [ A ] upload [ A ] 679
087752-15089 topoisomerase II alpha upload [ A ] upload [ A ] 679
089318-15695 topoisomerase II alpha upload [ A ] upload [ A ] 679


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu