Motion in Thymidylate Synthase [tms]

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Classification Known Fragment Motion, Shear Mechanism [F-s-2]

Structures
2TSC Conformation 2 [ PartsList ]
3TMS Conformation 1 [ PartsList ]

Description
Small shear motion of helices packed onto central sheet.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

References
W R Montfort, K M Perry, E B Fauman, J S Finermoore, G F Maley, L Hardy, F Maley and R M Stroud (1990). Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an antifolate. Biochemistry. 29: 6964-6977. [Medline info for 91288486]
K M Perry, E B Fauman, J S Finer-Moore, W R Montfort, G F Maley, F Maley and R M Stroud (1990). Plastic Adaption Toward Mutations in Proteins: Structural Comparison of Thymidylate Synthases. Proteins: Struc. Func. Genet. 8: 315. [Medline info for 91288486]