Motion in Thymidylate Synthase [tms]

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Classification Known Fragment Motion, Shear Mechanism [F-s-2]

Structures 2TSC Conformation 2 [ PartsList ] 3TMS Conformation 1 [ PartsList ]

Description Small shear motion of helices packed onto central sheet.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References W R Montfort, K M Perry, E B Fauman, J S Finermoore, G F Maley, L Hardy, F Maley and R M Stroud (1990). Structure, multiple site binding, and segmental accommodation in thymidylate synthase on binding dUMP and an antifolate. Biochemistry. 29: 6964-6977. [Medline info for 91288486] K M Perry, E B Fauman, J S Finer-Moore, W R Montfort, G F Maley, F Maley and R M Stroud (1990). Plastic Adaption Toward Mutations in Proteins: Structural Comparison of Thymidylate Synthases. Proteins: Struc. Func. Genet. 8: 315. [Medline info for 91288486]

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu