Motion in Themolysin, Elastase, neutral proteases [thermo]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1EZM Conformation 1 [ PartsList ] 4TMN Conformation 2 [ PartsList ]

Description Bending interdomain helix

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References D R Holland, D E Tronrud, H W Pley, K M Flaherty, W Stark, J N Jansonius, D B McKay and B W Matthews (1992). Structural Comparison Suggests That Thermolysin and Related Neutral Proteases Undergo Hinge-Bending Motion During Catalysis. Biochemistry. 31: 11310-11316. [Medline info for 93376766] M M Thayer, K M Flaherty and D B McKay (1991). Three-Dimensional Structure of the Elastase of Pseudomonas aeruginosa at 1.5 Å Resolution. J. Biol. Chem. 266: 2864-2871. [Medline info for 93376766]

GO terms associated with structures Molecular function metallopeptidase activity, zinc ion binding, metalloendopeptidase activity Cellular component extracellular region Biological process proteolysis and peptidolysis

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu