Motion in Triglyceride Lipase [tgl]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures 1TGL Conformation 1 [ PartsList ] 4TGL Conformation 2 [ PartsList ]

Description 2 hinges on either side of a helix move CA atoms up to12 Angstrom. In one hinge a residue changes from an extended to a helical conformation.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References U Derewenda, A M Brzozowski, D M Lawson and Z S Derewenda (1992). Catalysis at the Interface: The Anatomy of a Conformational Change in a Triglyceride Lipase. Biochemistry. 31: 1532-1541. [Medline info for 93376766]

GO terms associated with structures Molecular function catalytic activity, triacylglycerol lipase activity Biological process lipid metabolism

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu