Motion in Transducin-a [tducin]

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Classification Suspected Domain Motion, Unclassifiable Mechanism [D-?-1]

Structures 1TAG Conformation 1 [ PartsList ] 1TNG Conformation 2 [ PartsList ]

Description Heterotrimeric G protein has been solved in at least three Similar movements to EF-Tu and ras expected conformations: Unbound, bound to GTP-gamma S and bound to GTP.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References D G Lambright, J P Noel, H E Hamm, and P B Sigler (1994). Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369:621-628. [Medline info for 93376766] J P Noel, H E Hamm and P B Sigler (1993). The 2.2 Å crystal structure of transducin-a complexed with GTPgS. Nature. 366: 654-663. [Medline info for 93376766]

GO terms associated with structures Molecular function chymotrypsin activity, signal transducer activity, trypsin activity, GTP binding Biological process proteolysis and peptidolysis, signal transduction, G-protein coupled receptor protein signaling pathway

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu