Motion in S100 Calcium sensor [s100]

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Classification [F-s-2]

Structures
1K9P wild-type
1K9K Ca-bound
1K96 Ca-bound (C2 form)
1K8U Ca-free mutant

Description
Similar to calmodulin and troponin; motion involves change in conformation of overall dimer as well as movement in helices.

References
Ludovic R Otterbein, Jolanta Kordowska, Carlos Witte-Hoffmann, C-L Albert Wang, Roberto Dominguez (2002). Crystal Structures of S100A6 in the Ca(2+)-Free and Ca(2+)-Bound States. The Calcium Sensor Mechanism of S100 Proteins Revealed at Atomic Resolution. Structure (Camb), 10:557-67 [Medline info for 11937060]

GO terms associated with structures
Molecular functioncalcium ion binding

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
S100A6 1k9p [ A ] 1k9k [ A ] 90

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
107049-27710 Calcium Sensor 1k9p [ A ] 1k9k [ A ] 90
107089-27732 Calcium Sensor 1k9p [ A ] 1k96 [ A ] 90
107308-28361 Calcium Sensor 1k96 [ A ] 1k9k [ A ] 90
133274-4926 S100 Calcium Sensor 1k9p [ A ] 1k9k [ A ] 90
134589-5767 S100 Calcium Sensor 1k9p [ A ] 1k9k [ A ] 90
963396-10630 S100A6 1k9k [ A ] 1k96 [ A ] 90

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1qlkB-1symB S-100 Protein 1qlk [ B ] 1sym [ B ] 92
va1qlkA-1symB S-100 Protein 1qlk [ A ] 1sym [ B ] 92
va1qlkA-1symA S-100 Protein 1qlk [ A ] 1sym [ A ] 92
va1qlkA-1b4cA S-100 Protein 1qlk [ A ] 1b4c [ A ] 92
va1mhoA-1cfpA S-100 Protein 1mho [ A ] 1cfp [ A ] 92
va1qlkA-1dt7A S-100 Protein 1qlk [ A ] 1dt7 [ A ] 92
va1qlkA-1dt7B S-100 Protein 1qlk [ A ] 1dt7 [ B ] 92
va1b4cB-1dt7B S-100 Protein, Beta Chain 1b4c [ B ] 1dt7 [ B ] 92
va1b4cB-1qlkB S-100 Protein, Beta Chain 1b4c [ B ] 1qlk [ B ] 92
va1b4cA-1qlkB S-100 Protein, Beta Chain 1b4c [ A ] 1qlk [ B ] 92
va1b4cB-1qlkA S-100 Protein, Beta Chain 1b4c [ B ] 1qlk [ A ] 92
va1b4cA-1symA S-100 Protein, Beta Chain 1b4c [ A ] 1sym [ A ] 92
va1b4cB-1symB S-100 Protein, Beta Chain 1b4c [ B ] 1sym [ B ] 92
va1b4cB-1symA S-100 Protein, Beta Chain 1b4c [ B ] 1sym [ A ] 92
va1dt7B-1symA S100 Calcium-Binding Protein 1dt7 [ B ] 1sym [ A ] 92
va1dt7A-1b4cA S100 Calcium-Binding Protein 1dt7 [ A ] 1b4c [ A ] 92
va1dt7A-1b4cB S100 Calcium-Binding Protein 1dt7 [ A ] 1b4c [ B ] 92
va1dt7B-1b4cA S100 Calcium-Binding Protein 1dt7 [ B ] 1b4c [ A ] 92
va1dt7A-1qlkB S100 Calcium-Binding Protein 1dt7 [ A ] 1qlk [ B ] 92
va1dt7B-1qlkB S100 Calcium-Binding Protein 1dt7 [ B ] 1qlk [ B ] 92
va1symB-1dt7A S100B 1sym [ B ] 1dt7 [ A ] 92
va1symB-1dt7B S100B 1sym [ B ] 1dt7 [ B ] 92
va1symA-1dt7A S100B 1sym [ A ] 1dt7 [ A ] 92
va1symA-1qlkB S100B 1sym [ A ] 1qlk [ B ] 92
va1cfpB-1mhoA S100B 1cfp [ B ] 1mho [ A ] 88
va1symB-1b4cA S100B 1sym [ B ] 1b4c [ A ] 92

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu