Motion in Ras Protein [ras]
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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]
Structures 4Q21 Conformation 1 [ PartsList ] 6Q21 Conformation 2 [ PartsList ]
Description 2 loop movements move CA atoms up to 10 Angstrom (one movement includes helix attached to loop). The small G-proteins Rap, Rac and Rho have similar folds and motions. Ran has a similar fold, but a much larger and more complex motion.
Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = tx (Time-resolved and traditional X-ray structures)
References M V Milburn, L Tong, A DeVos, A Brünger, Z Yamaizumi, S Nishimura and S-H Kim (1990). Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins. Science. 247: 939-945. [Medline info for 97074462] I Schlichting, S C Almo, G Rapp, K Wilson, K Petratos, A Lentfer, A Wittinghofer, W Kabsch, E F Pai, G A Petsko and R S Goody (1990). Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis. Nature. 345: 309. [Medline info for 97074462] E F Pai, U Krengel, G A Peetsko, R S Goody, W Kabsch, and A Wittinghofer (1990). Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis. EMBO Journ. 9:2351-2359. [Medline info for 90316087]
Data and Graphics MPI : GTP-binding proteins Home page for laboratories at MPI studying Ras and related structures. Experimental method: Time-resolved x-ray crystallography Information on the time-resolved x-ray crystallography method
GO terms associated with structures Molecular function GTP binding Biological process small GTPase mediated signal transduction
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu