Motion in Motion of the Purine Repressor upon binding DNA [purrdna]

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Classification Known Fragment Motion, Unclassifiable [F-?-2]

Structures 1PNR X-ray struc. of whole molecule bound to DNAComplex [ PartsList ] 1PRU NMR struc. of 3-helix head-piece not bound to DNAApo [ PartsList ] 1PRV NMR struc. of 3-helix head-piece not bound to DNAApo [ PartsList ]

Description Upon binding DNA, part of the structure that was a disordered coil becomes an ordered helix. This helix is fourth helix of the HTH-headpiece domain. This finding is the result of comparing the unbound fragment structure (NMR, Nagadoi et al.) with the DNA-protein complex of structure (X-ray, Schumacher et al.).

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = xn (Traditional X-ray and NMR)

References M. A. Schumacher, K. Y. Choi, H. Zalkin & R. G. Brennan (1994). Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science 266: 763-770 [Medline info for 95063908]

GO terms associated with structures Molecular function transcription factor activity Cellular component intracellular Biological process regulation of transcription, DNA-dependent

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu