Motion in Allosteric Motion in the Purine Repressor [purrallo]

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Classification Suspected Subunit Motion, Involving Allostery [S-a-1]

Structures 1PNR X-ray struc. of whole molecule bound to DNAComplex [ PartsList ]

Description Part of this structure (the C-terminal corepressor binding domain) has similarities to the core domain of the lactose repressor (and to the bacterial periplasmic binding proteins). Regulation of DNA binding is expected to involve domain movements and similar allosteric conformational changes. However, PurR binds to DNA in the presence of the co-repressor, whereas LacR binds in the absence of the inducer.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References M. A. Schumacher, K. Y. Choi, H. Zalkin & R. G. Brennan (1994). Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices. Science 266: 763-770 [Medline info for 95063908]

GO terms associated with structures Molecular function transcription factor activity Cellular component intracellular Biological process regulation of transcription, DNA-dependent

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu