Motion in DNA Polymerase Beta (Pol Beta) [polbeta]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures 1BPD Conformation 1 [ PartsList ] 2BPF Conformation 2 [ PartsList ] 2BPG Conformation 3 [ PartsList ]

Description Pol Beta contains 4 domains: 8-kD, F, P, and T. In both apo and ternary complexes the F, P, and T domains are arranged in such a way as to form a cleft for the DNA. In apo form the 8-kD domain, which is connected to the F domain, is moved away from the cleft. In the ternary complexes the 8-kD domain closes over the cleft to varying degrees through the motion of a singe flexible hinge of about 10 residues.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References M R Sawaya, H Pelletier, A Kumar, S H Wilson and J Kraut (1994). Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science. 264: 1930-5. [Medline info for 94278498]

GO terms associated with structures Molecular function beta DNA polymerase activity, DNA binding, DNA-directed DNA polymerase activity Cellular component intracellular Biological process DNA replication, DNA repair

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu