Motion in Methylene-Tetrahydromethanopterin Dehydrogenase [mtda]

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Classification [D-h-2]

Structures
1LUA
1LU9

Description
NADP+ binding changes the conformation of the NADP domain relative to the pterin domain. The rotation of about 6 degrees causes an opening of the interdomain crevice. It is probable that NADP+ binding freezes a particular conformational state of uncomplexed MdtA rather than inducing a conformational change.

References
Ulrich Ermler, Christoph Hagemeier, Annette Roth, Ulrike Demmer, Wolfgang Grabarse, Eberhard Warkentin, Julia Vorholt (2002). Structure of Methylene-Tetrahydromethanopterin Dehydrogenase from Methylobacterium extorquens AM1. Structure (Camb), 10:1127 [Medline info for 12176390]
J A Vorholt, L Chistoserdova, M E Lidstrom, R K Thauer (1998). The NADP-dependent methylene tetrahydromethanopterin dehydrogenase in Methylobacterium extorquens AM1. J Bacteriol, 180:5351-6 [Medline info for 9765566]

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
methylene-H4MPT dehydrogenase 1lua [ A ] 1lu9 [ A ] 287



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu