Motion in Malate Dehydrogenase (MDH) [mdh]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures 4MDH Conformation 1 [ PartsList ]

Description Comparison of subunits shows a loop closure similar to LDH, moving atom CA atoms up to 8 Angstrom. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion Creation Date = 19970822 Modification Date = 19970822 Experimental Methods = x (Traditional x-ray)

References J J Birktoft, G Rhodes and L J Banaszak (1989). Refined Crystal Structure of Cytoplasmic Malate Dehydrogenase at 2.5 Å Resolution. Biochemistry. 28: 6065. [Medline info for 93041761]

GO terms associated with structures Molecular function L-lactate dehydrogenase activity, malate dehydrogenase activity, L-malate dehydrogenase activity, oxidoreductase activity Biological process glycolysis, tricarboxylic acid cycle intermediate metabolism, malate metabolism

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues Via_align 4mdh [ A ] 1bmd [ A ] 327

User-submitted morphs Morph Morph name Structure #1 Structure #2 Residues 85114-3443 5ldh 5ldh [ A ] 4mdh [ A ] 333

Automatic morphs Morph Morph name Structure #1 Structure #2 Residues va1ie3D-2cmdA Malate Dehydrogenase 1ie3 [ D ] 2cmd [ A ] 312

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu