Motion in Malate Dehydrogenase (MDH) [mdh]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
4MDH Conformation 1 [ PartsList ]

Description
Comparison of subunits shows a loop closure similar to LDH, moving atom CA atoms up to 8 Angstrom. Motion is evident in comparing different subunits in the asymmetric unit. Single data bank identifier applies for both forms.

Particular values describing motion
Creation Date = 19970822
Modification Date = 19970822
Experimental Methods = x (Traditional x-ray)

References
J J Birktoft, G Rhodes and L J Banaszak (1989). Refined Crystal Structure of Cytoplasmic Malate Dehydrogenase at 2.5 Å Resolution. Biochemistry. 28: 6065. [Medline info for 93041761]

GO terms associated with structures
Molecular functionoxidoreductase activity, L-lactate dehydrogenase activity, malate dehydrogenase activity, L-malate dehydrogenase activity
Biological processmalate metabolism, glycolysis, tricarboxylic acid cycle intermediate metabolism

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Via_align 4mdh [ A ] 1bmd [ A ] 327

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
85114-3443 5ldh 5ldh [ A ] 4mdh [ A ] 333

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1ie3D-2cmdA Malate Dehydrogenase 1ie3 [ D ] 2cmd [ A ] 312

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu