Motion in Spindle Assembly Checkpoint Protein [mad2]

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Classification [D-f-2]

Structures
1DUJ free
1KLQ peptide-bound

Description
Binding of peptide induces large rearrangement of beta sheet, with strands transposing to the opposite side of the structure. A smaller beta strand becomes helical.
Changes in beta fold are relatively uncommon, seen only in the serpins and the caspase inhibitor.

References
Xuelian Luo, Zhanyun Tang, Josep Rizo, Hongtao Yu (2002). The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell, 9:59-71 [Medline info for 11804586]
X Luo, G Fang, M Coldiron, Y Lin, H Yu, M W Kirschner, G Wagner (2000). Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol, 7:224-9 [Medline info for 10700282]

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Spindle Assembly Checkpoint Pr 1duj [ A ] 1klq [ A ] 197



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu