Motion in Luciferase [luciferase]

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Classification [D-s-2]

Structures
1BA3
1LCI [ PartsList ]

Description
Smaller C-terminal domain is thought to move towards the N-terminal domain upon binding of luciferin and ATP. Structures 1LCI and 1BA3 are native and with bromoform, respectively.

References
N P Franks, A Jenkins, E Conti, W R Lieb, P Brick (1998). Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J, 75:2205-11 [Medline info for 9788915]
E Conti, N P Franks, P Brick (1996). Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure, 4:287-98 [Medline info for 8805533]

GO terms associated with structures
Molecular functioncatalytic activity
Biological processmetabolism

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Luciferase 1ba3 [ A ] 1lci [ A ] 550

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
684051-1733 Firefly Luciferase upload [ A ] upload [ A ] 533
687142-3173 Firefly Luciferase upload [ A ] upload [ A ] 533
690174-7548 Firefly Luciferase upload [ A ] upload [ A ] 540
755396-18159 firefly luciferase upload [ A ] upload [ A ] 540
752001-14309 Luciferase upload [ A ] upload [ A ] 540
754312-15457 luciferase upload [ A ] upload [ A ] 533


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu