Motion in Luciferase [luciferase]

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Classification [D-s-2]

Structures 1BA3 1LCI [ PartsList ]

Description Smaller C-terminal domain is thought to move towards the N-terminal domain upon binding of luciferin and ATP. Structures 1LCI and 1BA3 are native and with bromoform, respectively.

References N P Franks, A Jenkins, E Conti, W R Lieb, P Brick (1998). Structural basis for the inhibition of firefly luciferase by a general anesthetic. Biophys J, 75:2205-11 [Medline info for 9788915] E Conti, N P Franks, P Brick (1996). Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes. Structure, 4:287-98 [Medline info for 8805533]

GO terms associated with structures Molecular function catalytic activity Biological process metabolism

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu