Motion in Lac Repressor (Order-disorder transition of headpiece linker upon binding DNA) [lacrdna]

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Classification Known Fragment Motion, Neither Hinge nor Shear Mechanism [F-n-2]

Structures
1LCC NMR structure of HTH-headpiece with DNAComplex [ PartsList ]
1LCD NMR structure of HTH-headpiece with DNA (Best structure)Complex [ PartsList ]

Description
Linker region undergoes an unstructured coil to helix transition in the presence of DNA.

Particular values describing motion
Experimental Methods = xn (Traditional X-ray and NMR)
Creation Date = 19970822
Modification Date = 19970822

References
V. P. Chuprina, J. A. Rullmann, R. M. Lamerichs, J. H. van Boom, R. Boelens & R. Kaptein Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J Mol Biol 234: 446-62 (1993) [Medline info for 94047092]

GO terms associated with structures
Molecular functiontranscription factor activity
Cellular componentintracellular
Biological processregulation of transcription, DNA-dependent

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu