Motion in Lac Repressor (Order-disorder transition of headpiece linker upon binding DNA) [lacrdna]
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Classification Known Fragment Motion, Neither Hinge nor Shear Mechanism [F-n-2]
Structures 1LCC NMR structure of HTH-headpiece with DNAComplex [ PartsList ] 1LCD NMR structure of HTH-headpiece with DNA (Best structure)Complex [ PartsList ]
Description Linker region undergoes an unstructured coil to helix transition in the presence of DNA.
Particular values describing motion Experimental Methods = xn (Traditional X-ray and NMR) Creation Date = 19970822 Modification Date = 19970822
References V. P. Chuprina, J. A. Rullmann, R. M. Lamerichs, J. H. van Boom, R. Boelens & R. Kaptein Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics. J Mol Biol 234: 446-62 (1993) [Medline info for 94047092]
GO terms associated with structures Molecular function transcription factor activity Cellular component intracellular Biological process regulation of transcription, DNA-dependent
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu