Motion in Lac Repressor Core (Allosteric Motion) [lacrallo]

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Classification Known Subunit Motion, Involving Allostery [S-a-2]

1LBG Tetramer bound to DNAComplex [ PartsList ]
1LBH With inducer IPTGOpen [ PartsList ]
1LBI Without inducer or DNA (head-piece disordered)Closed [ PartsList ]
1TLF 2.6 A X-ray structure of core domain with inducer and tet. domain (no headpiece)Open [ PartsList ]

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

Lewis M; Chang G; Horton NC; Kercher MA; Pace HC; Schumacher MA; Brennan RG; Lu P. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer [see comments]. Science, 1996 Mar 1, 271(5253):1247-54. [Medline info for 96239623]

GO terms associated with structures
Molecular functiontranscription factor activity
Cellular componentintracellular
Biological processregulation of transcription, DNA-dependent

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Email: Mark.Gerstein _at_