Motion in Lac Repressor Core (Allosteric Motion) [lacrallo]

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Classification Known Subunit Motion, Involving Allostery [S-a-2]

Structures 1LBG Tetramer bound to DNAComplex [ PartsList ] 1LBH With inducer IPTGOpen [ PartsList ] 1LBI Without inducer or DNA (head-piece disordered)Closed [ PartsList ] 1TLF 2.6 A X-ray structure of core domain with inducer and tet. domain (no headpiece)Open [ PartsList ]

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References Lewis M; Chang G; Horton NC; Kercher MA; Pace HC; Schumacher MA; Brennan RG; Lu P. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer [see comments]. Science, 1996 Mar 1, 271(5253):1247-54. [Medline info for 96239623]

GO terms associated with structures Molecular function transcription factor activity Cellular component intracellular Biological process regulation of transcription, DNA-dependent

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu