Motion in Kinesin-like KIF1A Motor Domain [kif1a]
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Structures 1I6I 1I5S
Description KIF1A is a monomeric kinesin motor, which use hydrolysis ATP to generate force and movement along microtubule. The movie was generated from two functionally critical state --- complexed with ADP and with a non-hydrolysable analogue of ATP. The conformational change observed between these two structure is similar to the conformational change used by myosin motors and G proteins.
References M Kikkawa, E P Sablin, Y Okada, H Yajima, R J Fletterick, N Hirokawa (2001). Switch-based mechanism of kinesin motors. Nature, 411:439-45 [Medline info for 11373668] M Kikkawa, Y Okada and N Hirokawa (2000). 15A Resolution Model of the Monomeric Kinesin Motor, KIF1A. Cell, 100:241-252.
Data and Graphics Online review Article on kinesin motor structures at the LBL Advanced Light Source.
GO terms associated with structures Molecular function ATP binding, microtubule motor activity Cellular component microtubule associated complex Biological process microtubule-based movement
Morphs[ show all images ]
Best representative Morph Morph name Structure #1 Structure #2 Residues KIF1A Motor Domain 1i6i [ A ] 1i5s [ A ] 330
User-submitted morphs Morph Morph name Structure #1 Structure #2 Residues KIF1A 1i6i [ A ] 1i5s [ A ] 367 KIF1A 1i5s [ A ] 1i6i [ A ] 366 KIF1A with ATP/ADP 1i6i [ A ] 1i5s [ A ] 367
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu