Motion in Kinesin-like KIF1A Motor Domain [kif1a]

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Classification [D-s-2]

Structures 1I6I 1I5S

Description KIF1A is a monomeric kinesin motor, which use hydrolysis ATP to generate force and movement along microtubule. The movie was generated from two functionally critical state --- complexed with ADP and with a non-hydrolysable analogue of ATP. The conformational change observed between these two structure is similar to the conformational change used by myosin motors and G proteins.

References M Kikkawa, E P Sablin, Y Okada, H Yajima, R J Fletterick, N Hirokawa (2001). Switch-based mechanism of kinesin motors. Nature, 411:439-45 [Medline info for 11373668] M Kikkawa, Y Okada and N Hirokawa (2000). 15A Resolution Model of the Monomeric Kinesin Motor, KIF1A. Cell, 100:241-252.

Data and Graphics Online review Article on kinesin motor structures at the LBL Advanced Light Source.

GO terms associated with structures Molecular function microtubule motor activity, ATP binding Cellular component microtubule associated complex Biological process microtubule-based movement

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu