Motion in Kinesin-like KIF1A Motor Domain [kif1a]

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Classification [D-s-2]

Structures
1I6I
1I5S

Description
KIF1A is a monomeric kinesin motor, which use hydrolysis ATP to generate force and movement along microtubule. The movie was generated from two functionally critical state --- complexed with ADP and with a non-hydrolysable analogue of ATP. The conformational change observed between these two structure is similar to the conformational change used by myosin motors and G proteins.

References
M Kikkawa, E P Sablin, Y Okada, H Yajima, R J Fletterick, N Hirokawa (2001). Switch-based mechanism of kinesin motors. Nature, 411:439-45 [Medline info for 11373668]
M Kikkawa, Y Okada and N Hirokawa (2000). 15A Resolution Model of the Monomeric Kinesin Motor, KIF1A. Cell, 100:241-252.

Data and Graphics
Online review Article on kinesin motor structures at the LBL Advanced Light Source.

GO terms associated with structures
Molecular functionmicrotubule motor activity, ATP binding
Cellular componentmicrotubule associated complex
Biological processmicrotubule-based movement

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
KIF1A Motor Domain 1i6i [ A ] 1i5s [ A ] 330

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
141831-19136 KIF1A 1i6i [ A ] 1i5s [ A ] 367
051522-9949 KIF1A 1i5s [ A ] 1i6i [ A ] 366
133937-16679 KIF1A with ATP/ADP 1i6i [ A ] 1i5s [ A ] 367


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu