Motion in Isocitrate Dehydrogenase (IDH) [idh]

[ jump to morphs ]

Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
1AI2 Complexed with isocitrate [ PartsList ]
1IKA Complexed with a-ketoglutarate [ PartsList ]
3ICD Free IDH [ PartsList ]
4ICD Phosphorylated [ PartsList ]
5ICD Complex With Mg2+ and Isocitrate [ PartsList ]

Description
Loop movements of ~2 Angstrom.

Particular values describing motion
Experimental Methods = xm (Traditional X-ray and molecular dynamics)
Creation Date = 19970822
Modification Date = 19970822

References
A D Mesecar, B L Stoddar, D E Koshland Jr. (1997) Oribital Steering in the Catalytic Power of Enzymes: Small Structural Changes with Large Catalytic Consequences. Sci. 277:202-206. [Medline info for 93945018]
B L Stoddard and J D.E. Koshland (1993). Structure of isocitrate dehydrogenase with a-ketoglutarate at 2.7 Å resolution: conformational changes induced by decarboxylation of isocitrate. Biochemistry. 32: 9317-9322. [Medline info for 93945018]

GO terms associated with structures
Molecular functionoxidoreductase activity, isocitrate dehydrogenase (NADP+) activity
Biological processtricarboxylic acid cycle, metabolism

Morphs

[ show all images ]
Best representative
Morph Morph name Structure #1 Structure #2 Residues
Isocitrate dehdrogenase 3icd [ A ] 1ai2 [ A ] 416

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
425937-24539 IDH 3icd [ A ] 1ika [ A ] 416
521167-32154 Isocitrate dehydrogenase 3icd [ A ] 1ika [ A ] 416


[help] [home] [movies]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu