Motion in Hhal Methyltransferase [hmetrn]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures 1HMY Conformation 1 [ PartsList ]

Description Upon binding DNA, loop closure with 2 hinges moves atoms up to 25 A so that they can bind to DNA. Small shearing motions of other domain.

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References S Klimasauskas, S Kumar, R J Roberts and X Cheng (1994). Hhal Methyltransferase flips its target base out the DNA helix. Cell. 76: 357-369. [Medline info for 9539134] X Cheng, S Kumar, J Posfai, J W Pflugrath and R J Roberts (1993). Crystal structure of the HhaI DNA methyltransferase complexed with S- adenosyl-L-methionine. Cell. 74: 299-307. [Medline info for 93945018]

GO terms associated with structures Molecular function DNA binding Biological process DNA methylation

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu