Motion in Hhal Methyltransferase [hmetrn]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
1HMY Conformation 1 [ PartsList ]

Description
Upon binding DNA, loop closure with 2 hinges moves atoms up to 25 A so that they can bind to DNA. Small shearing motions of other domain.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
S Klimasauskas, S Kumar, R J Roberts and X Cheng (1994). Hhal Methyltransferase flips its target base out the DNA helix. Cell. 76: 357-369. [Medline info for 9539134]
X Cheng, S Kumar, J Posfai, J W Pflugrath and R J Roberts (1993). Crystal structure of the HhaI DNA methyltransferase complexed with S- adenosyl-L-methionine. Cell. 74: 299-307. [Medline info for 93945018]

GO terms associated with structures
Molecular functionDNA binding
Biological processDNA methylation

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
HhaI methyltransfera upload [ A ] upload [ A ] 327

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
18098-26671 HhaI G88P upload [ A ] upload [ A ] 327
18286-26840 M.HhaI G88A upload [ A ] upload [ A ] 327
18201-26816 M.HhaI G88P upload [ A ] upload [ A ] 327

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va2hmyB-3mhtA Cytosine-Specific Methyltransf 2hmy [ B ] 3mht [ A ] 327
va7mhtA-2hmyB Cytosine-Specific Methyltransf 7mht [ A ] 2hmy [ B ] 327
va2hmyB-9mhtA Cytosine-Specific Methyltransf 2hmy [ B ] 9mht [ A ] 327
va8mhtA-1hmyA Cytosine-Specific Methyltransf 8mht [ A ] 1hmy [ A ] 327
va9mhtA-1hmyA Cytosine-Specific Methyltransf 9mht [ A ] 1hmy [ A ] 327
va8mhtA-2hmyB Cytosine-Specific Methyltransf 8mht [ A ] 2hmy [ B ] 327
va2hmyB-6mhtA Cytosine-Specific Methyltransf 2hmy [ B ] 6mht [ A ] 327
va2hmyB-10mhA Cytosine-Specific Methyltransf 2hmy [ B ] 10mh [ A ] 327
va1hmyA-3mhtA Hhai DNA (Cytosine-C5-)-Methyl 1hmy [ A ] 3mht [ A ] 327
va1hmyA-4mhtA Hhai DNA (Cytosine-C5-)-Methyl 1hmy [ A ] 4mht [ A ] 327
va1hmyA-7mhtA Hhai DNA (Cytosine-C5-)-Methyl 1hmy [ A ] 7mht [ A ] 327
va1hmyA-6mhtA Hhai DNA (Cytosine-C5-)-Methyl 1hmy [ A ] 6mht [ A ] 327
va1hmyA-10mhA Hhai DNA (Cytosine-C5-)-Methyl 1hmy [ A ] 10mh [ A ] 327
va1fjxA-2hmyB Hhai DNA Methyltransferase 1fjx [ A ] 2hmy [ B ] 327
va1fjxA-1hmyA Hhai DNA Methyltransferase 1fjx [ A ] 1hmy [ A ] 327
va4mhtA-2hmyB Hhai Methyltransferase 4mht [ A ] 2hmy [ B ] 327
va5mhtA-2hmyB Hhai Methyltransferase 5mht [ A ] 2hmy [ B ] 327
va5mhtA-1hmyA Hhai Methyltransferase 5mht [ A ] 1hmy [ A ] 327
va1mhtA-2hmyB Hhai Methyltransferase (E.C. 2 1mht [ A ] 2hmy [ B ] 327
va1mhtA-1hmyA Hhai Methyltransferase (E.C. 2 1mht [ A ] 1hmy [ A ] 327

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu