Motion in HIV-1 Reverse Transcriptase [hivrt]

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Classification Known Domain Motion, Partial Refolding of Structure [D-f-2]

Structures
1HMI Conformation 1 [ PartsList ]
3HVT Conformation 2 [ PartsList ]

Description
Comparison of subunits shows very large rearrangement of 2 of the 4 domains which is accomodated by changes in loops and by unfolding of small 3 stranded beta-sheet.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
J Jaeger, S J Smerdon, J Wang, D C Boisvert, and T A Steitz (1994). Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Struct. 2:869-876 [Medline info for 9539134]
J Wang, S J Smerdon, J Jaeger, L A Kohl, Staedt, P A Rice, J M Friedman (1994). Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. PNAS. 91:7242-7246 [Medline info for 9539134]
Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134]
L A Kohlstaedt, J Wang, J M Friedman, P A Rice and T A Steitz (1992). Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor. Science. 256: 1783-1790. [Medline info for 9539134]
A Jacobo-Molina, J Ding, R G Nanni, A D J Clark, X Lu, C Tantillo, R L Williams, G Kamer, A L Ferris, P Clark, A Hizi, S H Hughes and E Arnold (1993). Crystal Structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA. Proc. Natl. Acad. Sci. USA. 90: 6320-6324. [Medline info for 9539134]

GO terms associated with structures
Molecular functionintegrase activity, DNA binding, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity
Biological processRNA-dependent DNA replication, DNA integration, DNA recombination, proteolysis and peptidolysis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
HIV-1 Reverse Transc 2hmi [ A ] 3hvt [ A ] 556

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
1hmi [ ] 3hvt [ ] 556
HIV Reverse Transcriptase 1dlo [ A ] 1hni [ A ] 558
Hiv-1 Reverse Transcriptase upload [ A ] upload [ A ] 558
HIV-1 Reverse Transcriptase 1rev [ A ] 1rt1 [ A ] 559
HIV-1 reverse transcriptase upload [ A ] upload [ A ] 560
HIV-1 RT upload [ A ] upload [ A ] 556
HIV1 RT 1dlo [ A ] 1hys [ A ] 553
hivrt upload [ A ] upload [ A ] 556
Reverse Transcriptase 2hmi [ A ] 1rtd [ A ] 554

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hpz [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hpz [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hnv [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hnv [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ A ] 2hmi [ B ] 430
Hiv-1 Reverse Transcriptase 1hvu [ G ] 2hmi [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1hvu [ J ] 554
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1hvu [ D ] 554
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hvu [ A ] 554
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hvu [ G ] 554
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hys [ B ] 425
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hys [ B ] 425
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1dlo [ A ] 556
Hiv-1 Reverse Transcriptase 1hys [ A ] 1bqn [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hpz [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hvu [ A ] 554
Hiv-1 Reverse Transcriptase 1hys [ A ] 1bqm [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hvu [ D ] 554
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hvu [ G ] 554
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hvu [ J ] 554
Hiv-1 Reverse Transcriptase 1hys [ A ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1hys [ A ] 553
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hys [ A ] 553
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1hys [ A ] 553
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hys [ A ] 553
Hiv-1 Reverse Transcriptase 1hys [ A ] 2hmi [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1dlo [ A ] 556
Hiv-1 Reverse Transcriptase 1hys [ A ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1rtd [ C ] 554
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1rtd [ A ] 554
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1hni [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ B ] 1tvr [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ B ] 2hmi [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ B ] 1uwb [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1tvr [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ G ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ D ] 1hni [ A ] 558
Hiv-1 Reverse Transcriptase 1hvu [ J ] 1hni [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ A ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hnv [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ A ] 1bqn [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ A ] 1bqm [ A ] 556
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1bqn [ A ] 558
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1bqm [ A ] 556
Hiv-1 Reverse Transcriptase 2hmi [ A ] 1hni [ A ] 558
Hiv-1 Reverse Transcriptase 1hys [ B ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hnv [ B ] 427
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hpz [ B ] 430
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase 1hys [ B ] 1bqm [ B ] 430
Hiv-1 Reverse Transcriptase 1hys [ B ] 1bqn [ B ] 430
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1uwb [ B ] 427
Hiv-1 Reverse Transcriptase 2hmi [ B ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase 1hys [ B ] 1hni [ B ] 427
Hiv-1 Reverse Transcriptase 1hys [ B ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase 1hvu [ A ] 1dlo [ A ] 556
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1hvu [ A ] 554
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1hvu [ G ] 554
Hiv-1 Reverse Transcriptase (H 1hnv [ A ] 1bqn [ B ] 430
Hiv-1 Reverse Transcriptase (H 1hnv [ A ] 1bqm [ B ] 430
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1tvr [ A ] 558
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1hys [ A ] 553
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 2hmi [ A ] 558
Hiv-1 Reverse Transcriptase (H 1hnv [ A ] 1tvr [ B ] 427
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1uwb [ A ] 558
Hiv-1 Reverse Transcriptase (H 1hnv [ A ] 2hmi [ B ] 430
Hiv-1 Reverse Transcriptase (H 1hnv [ A ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 2hmi [ B ] 430
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1ikx [ B ] 427
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1hqu [ B ] 430
Hiv-1 Reverse Transcriptase (H 1hnv [ B ] 1hpz [ B ] 430
Human Immunodeficiency Virus T 1dlo [ A ] 1bqn [ B ] 430
Human Immunodeficiency Virus T 1dlo [ A ] 1hqu [ B ] 430
Human Immunodeficiency Virus T 1dlo [ A ] 1hpz [ B ] 430
Human Immunodeficiency Virus T 1dlo [ A ] 1hnv [ B ] 427
Human Immunodeficiency Virus T 1dlo [ A ] 1hni [ B ] 427
Human Immunodeficiency Virus T 1dlo [ A ] 1ikx [ B ] 427
Human Immunodeficiency Virus T 1dlo [ A ] 1hys [ B ] 425
Human Immunodeficiency Virus T 1hni [ A ] 1hpz [ B ] 430
Human Immunodeficiency Virus T 1hni [ A ] 1hqu [ B ] 430
Human Immunodeficiency Virus T 1hni [ B ] 1hys [ A ] 553
Human Immunodeficiency Virus T 1hni [ A ] 1bqn [ B ] 430
Human Immunodeficiency Virus T 1hni [ B ] 1hnv [ A ] 558
Human Immunodeficiency Virus T 1hni [ A ] 1bqm [ B ] 430
Human Immunodeficiency Virus T 1hni [ A ] 1hnv [ B ] 427
Human Immunodeficiency Virus T 1hni [ A ] 1tvr [ B ] 427
Human Immunodeficiency Virus T 1hni [ A ] 1ikx [ B ] 427
Human Immunodeficiency Virus T 1hni [ A ] 1hys [ B ] 425
Human Immunodeficiency Virus T 1dlo [ A ] 1hys [ A ] 553
Human Immunodeficiency Virus T 1dlo [ A ] 1tvr [ A ] 558
Human Immunodeficiency Virus T 1dlo [ A ] 1hnv [ A ] 558
Human Immunodeficiency Virus T 1hni [ A ] 1hvu [ A ] 554
Human Immunodeficiency Virus T 1hni [ A ] 1hvu [ G ] 554
Human Immunodeficiency Virus T 1dlo [ A ] 1bqm [ A ] 556
Human Immunodeficiency Virus T 1dlo [ A ] 1bqn [ A ] 558
Human Immunodeficiency Virus T 1dlo [ A ] 1hni [ A ] 558
Human Immunodeficiency Virus T 1hni [ A ] 1hys [ A ] 553
Human Immunodeficiency Virus T 1dlo [ A ] 1hvu [ G ] 554
Human Immunodeficiency Virus T 1dlo [ A ] 1hvu [ J ] 554
Human Immunodeficiency Virus T 1hni [ B ] 2hmi [ B ] 430
Human Immunodeficiency Virus T 1dlo [ A ] 1hvu [ D ] 554
Pol Polyprotein 1hpz [ B ] 1hvu [ A ] 554
Pol Polyprotein 1hpz [ B ] 1hvu [ G ] 554
Pol Polyprotein 1hpz [ B ] 1tvr [ A ] 558
Pol Polyprotein 1hpz [ B ] 1hys [ A ] 553
Pol Polyprotein 1hqu [ B ] 1hys [ A ] 553
Pol Polyprotein 1hpz [ B ] 1hnv [ A ] 558
Pol Polyprotein 1hqu [ B ] 1hnv [ A ] 558
Pol Polyprotein 1hpz [ B ] 1uwb [ A ] 558
Pol Polyprotein 1hqu [ B ] 1uwb [ A ] 558
Pol Polyprotein 1hqu [ B ] 1rtd [ C ] 554
Pol Polyprotein 1hqu [ B ] 1rtd [ A ] 554
Pol Polyprotein 1ikx [ B ] 1bqn [ A ] 558
Pol Polyprotein 1ikx [ B ] 1bqm [ A ] 556
Pol Polyprotein 1ikx [ B ] 1uwb [ A ] 558
Pol Polyprotein 1ikx [ B ] 1rtd [ C ] 554
Pol Polyprotein 1hpz [ B ] 2hmi [ B ] 430
Pol Polyprotein 1hqu [ B ] 2hmi [ B ] 430
Pol Polyprotein 1ikx [ B ] 2hmi [ B ] 430
Pol Polyprotein 1ikx [ B ] 1bqm [ B ] 430
Pol Polyprotein 1hpz [ B ] 1ikx [ B ] 427
Pol Polyprotein 1hqu [ B ] 1ikx [ B ] 427
Pol Polyprotein 1hpz [ B ] 1tvr [ B ] 427
Pol Polyprotein 1ikx [ B ] 1hni [ B ] 427
Pol Polyprotein 1hqu [ B ] 1tvr [ B ] 427
Reverse Transcriptase 1tvr [ B ] 1hvu [ J ] 554
Reverse Transcriptase 1bqm [ B ] 1dlo [ A ] 556
Reverse Transcriptase 1tvr [ B ] 1dlo [ A ] 556
Reverse Transcriptase 1uwb [ B ] 1dlo [ A ] 556
Reverse Transcriptase 1bqn [ A ] 1hpz [ B ] 430
Reverse Transcriptase 1bqn [ A ] 1hqu [ B ] 430
Reverse Transcriptase 1bqm [ A ] 1hpz [ B ] 430
Reverse Transcriptase 1bqm [ A ] 1hqu [ B ] 430
Reverse Transcriptase 1tvr [ A ] 1hqu [ B ] 430
Reverse Transcriptase 1bqn [ B ] 1tvr [ A ] 558
Reverse Transcriptase 1bqn [ A ] 1hni [ B ] 427
Reverse Transcriptase 1bqm [ B ] 1tvr [ A ] 558
Reverse Transcriptase 1bqm [ A ] 1hni [ B ] 427
Reverse Transcriptase 1bqn [ A ] 1hnv [ B ] 427
Reverse Transcriptase 1bqn [ B ] 2hmi [ A ] 558
Reverse Transcriptase 1tvr [ B ] 1bqn [ A ] 558
Reverse Transcriptase 1bqm [ A ] 1hnv [ B ] 427
Reverse Transcriptase 1tvr [ B ] 1bqm [ A ] 556
Reverse Transcriptase 1bqm [ B ] 2hmi [ A ] 558
Reverse Transcriptase 1rtd [ C ] 1hpz [ B ] 430
Reverse Transcriptase 1rtd [ A ] 1hpz [ B ] 430
Reverse Transcriptase 1tvr [ A ] 1hni [ B ] 427
Reverse Transcriptase 1bqn [ A ] 2hmi [ B ] 430
Reverse Transcriptase 1tvr [ B ] 2hmi [ A ] 558
Reverse Transcriptase 1bqm [ A ] 2hmi [ B ] 430
Reverse Transcriptase 1tvr [ A ] 1uwb [ B ] 427
Reverse Transcriptase 1uwb [ B ] 1hys [ A ] 553
Reverse Transcriptase 1uwb [ B ] 2hmi [ A ] 558
Reverse Transcriptase 1rtd [ C ] 1hnv [ B ] 427
Reverse Transcriptase 1uwb [ A ] 1hni [ B ] 427
Reverse Transcriptase 1rtd [ C ] 1hni [ B ] 427
Reverse Transcriptase 1tvr [ B ] 1rtd [ C ] 554
Reverse Transcriptase 1rtd [ A ] 1hnv [ B ] 427
Reverse Transcriptase 1rtd [ A ] 1hni [ B ] 427
Reverse Transcriptase 1tvr [ B ] 1rtd [ A ] 554
Reverse Transcriptase 1uwb [ A ] 1tvr [ B ] 427
Reverse Transcriptase 1uwb [ B ] 1hnv [ A ] 558
Reverse Transcriptase 1tvr [ A ] 2hmi [ B ] 430
Reverse Transcriptase 1tvr [ A ] 1ikx [ B ] 427
Reverse Transcriptase 1bqn [ A ] 1hys [ B ] 425
Reverse Transcriptase 1uwb [ B ] 1hni [ A ] 558
Reverse Transcriptase 1uwb [ A ] 2hmi [ B ] 430
Reverse Transcriptase 1bqm [ A ] 1hys [ B ] 425
Reverse Transcriptase 1rtd [ A ] 1ikx [ B ] 427
Reverse Transcriptase 1rtd [ C ] 1hys [ B ] 425
Reverse Transcriptase 1rtd [ A ] 1hys [ B ] 425
Reverse Transcriptase 1tvr [ A ] 1hvu [ D ] 554
Reverse Transcriptase 1tvr [ A ] 1hvu [ G ] 554
Reverse Transcriptase 1tvr [ A ] 1hvu [ J ] 554
Reverse Transcriptase 1uwb [ A ] 1dlo [ A ] 556
Reverse Transcriptase 1tvr [ A ] 2hmi [ A ] 558
Reverse Transcriptase 1tvr [ A ] 1hys [ A ] 553
Reverse Transcriptase 1uwb [ A ] 1hys [ A ] 553
Reverse Transcriptase 1uwb [ A ] 2hmi [ A ] 558
Reverse Transcriptase 1bqm [ B ] 2hmi [ B ] 430
Reverse Transcriptase 1uwb [ B ] 1hys [ B ] 425
Reverse Transcriptase 1bqn [ B ] 2hmi [ B ] 430
Reverse Transcriptase 1tvr [ B ] 1bqm [ B ] 430
Reverse Transcriptase 1tvr [ B ] 1bqn [ B ] 430
Reverse Transcriptase 1uwb [ B ] 1ikx [ B ] 427
Reverse Transcriptase 1tvr [ B ] 1ikx [ B ] 427
Reverse Transcriptase 1bqn [ B ] 1hnv [ B ] 427
Reverse Transcriptase 1uwb [ B ] 1hpz [ B ] 430
Reverse Transcriptase 1bqm [ B ] 1hnv [ B ] 427
Reverse Transcriptase 1uwb [ B ] 1hqu [ B ] 430

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu