Motion in HIV-1 Reverse Transcriptase [hivrt]

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Classification Known Domain Motion, Partial Refolding of Structure [D-f-2]

Structures 1HMI Conformation 1 [ PartsList ] 3HVT Conformation 2 [ PartsList ]

Description Comparison of subunits shows very large rearrangement of 2 of the 4 domains which is accomodated by changes in loops and by unfolding of small 3 stranded beta-sheet.

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References J Jaeger, S J Smerdon, J Wang, D C Boisvert, and T A Steitz (1994). Comparison of three different crystal forms shows HIV-1 reverse transcriptase displays an internal swivel motion. Struct. 2:869-876 [Medline info for 9539134] J Wang, S J Smerdon, J Jaeger, L A Kohl, Staedt, P A Rice, J M Friedman (1994). Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer. PNAS. 91:7242-7246 [Medline info for 9539134] Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134] L A Kohlstaedt, J Wang, J M Friedman, P A Rice and T A Steitz (1992). Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor. Science. 256: 1783-1790. [Medline info for 9539134] A Jacobo-Molina, J Ding, R G Nanni, A D J Clark, X Lu, C Tantillo, R L Williams, G Kamer, A L Ferris, P Clark, A Hizi, S H Hughes and E Arnold (1993). Crystal Structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 Å resolution shows bent DNA. Proc. Natl. Acad. Sci. USA. 90: 6320-6324. [Medline info for 9539134]

GO terms associated with structures Molecular function RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity, integrase activity, DNA binding Biological process RNA-dependent DNA replication, DNA integration, DNA recombination, proteolysis and peptidolysis

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu