Motion in HIV-1 protease [hivprot]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
1HHP Conformation5 [ PartsList ]
1HIV Conformation4 [ PartsList ]
3HVP Conformation 2 [ PartsList ]
4HVP Conformation 1 [ PartsList ]
5HVP Conformation 3 [ PartsList ]

Description
Two large loop regions, that together comprise one quarter of the structure, move CA atoms ~ 7 Angstrom

Particular values describing motion
Creation Date = 19970822
Experimental Methods = x (Traditional x-ray)
Modification Date = 1998-06-27 22:06:24.000

References
Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134]
M Miller, J Schneider, B K Sathyanarayana, M V Toth, G R Marshall, L Clawson, L Selk, S B H Kent and A Wlodawer (1989). Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 angstrom Resolution. Science. 246: 1149-52. [Medline info for 9539134]
P M D Fitzgerald, B M McKeever, J F VanMiddlesworth, J P Springer, J C Heimbach, C-T Leu, W K Herber, R A F Dixon and P L Darke (1990). Crystallographic Analysis of a Complex between Human Immunodeficiency Virus Type 1 Protease and Acetyl-Pepstatin at 2.0 angstrom Resolution. J. Biol. Chem. 265: 14209-14219. [Medline info for 9539134]

GO terms associated with structures
Molecular functionintegrase activity, DNA binding, RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity
Biological processRNA-dependent DNA replication, DNA integration, DNA recombination, proteolysis and peptidolysis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
4hvp [ ] 3hvp [ ] 99

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
HIV Prot upload [ A ] upload [ A ] 97
HIV Protease 1hvp [ A ] 9hvp [ A ] 99
hiv protease 4hvp [ A ] 3hvp [ A ] 99
hiv protease 1hvr [ A ] 1hhp [ A ] 99
HIV protease 1hvr [ A ] 1hhp [ A ] 99
HIV-1 1ajv [ A ] 1hvr [ A ] 99
HIV-1 Protease 1hiv [ A ] 1fb7 [ A ] 99
HIV-1 protease 1hhp [ A ] 7hvp [ A ] 97
HIV-1 Protease 7hvp [ A ] 1hsg [ A ] 99
HIV-1 Protease 7hvp [ A ] 1hsg [ A ] 99
HIV-1 protease upload [ A ] upload [ A ] 198
HIV-1 protease 16 fr 4hvp [ A ] 3hvp [ A ] 99
HIV-1 protease 24 fr 4hvp [ A ] 3hvp [ A ] 99
HIV-1 protease 8 fra 4hvp [ A ] 3hvp [ A ] 99
HIV-Protease I upload [ A ] upload [ A ] 99

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
Aspartylprotease 1ohr [ B ] 1hvp [ A ] 99
Aspartylprotease 1ohr [ B ] 1hvp [ B ] 99
Aspartylprotease 1ohr [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1g35 [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1ajv [ B ] 1hvp [ A ] 99
Hiv-1 Protease 2upj [ B ] 1hvp [ B ] 99
Hiv-1 Protease 2bpz [ B ] 1hvp [ A ] 99
Hiv-1 Protease 2bpw [ B ] 1hvp [ A ] 99
Hiv-1 Protease 1ajv [ A ] 1hvp [ A ] 99
Hiv-1 Protease 2bpz [ B ] 1hvp [ B ] 99
Hiv-1 Protease 1hsg [ B ] 1hvp [ A ] 99
Hiv-1 Protease 2bpv [ B ] 1hvp [ A ] 99
Hiv-1 Protease 2bpz [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1ajx [ B ] 1hvp [ A ] 99
Hiv-1 Protease 1ajx [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1hpx [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1hpx [ A ] 1hvp [ B ] 99
Hiv-1 Protease 2bpx [ B ] 1hvp [ A ] 99
Hiv-1 Protease 1g35 [ B ] 1hvp [ B ] 99
Hiv-1 Protease 1g35 [ A ] 1hvp [ B ] 99
Hiv-1 Protease 7upj [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1ajv [ B ] 1hvp [ B ] 99
Hiv-1 Protease 2bpy [ B ] 1hvp [ A ] 99
Hiv-1 Protease 1ajx [ B ] 1hvp [ B ] 99
Hiv-1 Protease 1dif [ B ] 1hvp [ B ] 99
Hiv-1 Protease 2upj [ A ] 1hvp [ B ] 99
Hiv-1 Protease 1hpx [ B ] 1hvp [ A ] 99
Hiv-1 Protease 1dif [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1dif [ A ] 1hvp [ B ] 99
Hiv-1 Protease 1upj [ A ] 1hvp [ A ] 99
Hiv-1 Protease 1gno [ A ] 1hvp [ A ] 99
Hiv-1 Protease (Bru Isolate) - 1hhp [ A ] 1hvp [ A ] 99
Hiv-1 Protease (E.C. 3.4.23.-) 1hih [ B ] 1hvp [ A ] 99
Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ A ] 1hvp [ A ] 99
Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ B ] 1hvp [ A ] 99
Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ A ] 1hvp [ B ] 99
Hiv-1 Protease Complex With Sb 1hos [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complex With Sb 1hos [ A ] 1hvp [ A ] 99
Hiv-1 Protease Complex With Sb 1hos [ A ] 1hvp [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 3phv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2upj [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 7upj [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpx [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1c70 [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2bpy [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2bpv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpw [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hte [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvj [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvk [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpx [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2upj [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvi [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hvj [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvj [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvi [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1gno [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hvl [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1gno [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1htf [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1gno [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1upj [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hos [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hpv [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hbv [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 3phv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hhp [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hte [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hte [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1g2k [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1g35 [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 7upj [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 7upj [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2bpx [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpw [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1ajv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpy [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1htg [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hsg [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpv [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpz [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 2bpw [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1ajx [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 2bpy [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1htg [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1htg [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hsg [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hsg [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1dif [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvl [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hih [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hih [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hih [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hvk [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hpx [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvk [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1ohr [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hvi [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1htf [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1htf [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hps [ B ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hvl [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ A ] 1hbv [ A ] 99
HIV-1 Protease Complex With Su 1hvp [ B ] 1hbv [ A ] 99
Hiv-1 Protease Complexed With 1hte [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hvk [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hps [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hps [ A ] 1hvp [ B ] 99
Hiv-1 Protease Complexed With 1hbv [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1htg [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hvj [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hvl [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hvi [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1htf [ B ] 1hvp [ A ] 99
Hiv-1 Protease Complexed With 1hps [ A ] 1hvp [ A ] 99
Protease 1c70 [ B ] 1hvp [ A ] 99
Protease 1c70 [ B ] 1hvp [ B ] 99
Protease 1c70 [ A ] 1hvp [ A ] 99
Protease Retropepsin 1g2k [ B ] 1hvp [ A ] 99
Protease Retropepsin 1g2k [ B ] 1hvp [ B ] 99
Protease Retropepsin 1g2k [ A ] 1hvp [ B ] 99

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu