Motion in HIV-1 protease [hivprot]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
1HHP Conformation5 [ PartsList ]
1HIV Conformation4 [ PartsList ]
3HVP Conformation 2 [ PartsList ]
4HVP Conformation 1 [ PartsList ]
5HVP Conformation 3 [ PartsList ]

Description
Two large loop regions, that together comprise one quarter of the structure, move CA atoms ~ 7 Angstrom

Particular values describing motion
Creation Date = 19970822
Experimental Methods = x (Traditional x-ray)
Modification Date = 1998-06-27 22:06:24.000

References
Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134]
M Miller, J Schneider, B K Sathyanarayana, M V Toth, G R Marshall, L Clawson, L Selk, S B H Kent and A Wlodawer (1989). Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 angstrom Resolution. Science. 246: 1149-52. [Medline info for 9539134]
P M D Fitzgerald, B M McKeever, J F VanMiddlesworth, J P Springer, J C Heimbach, C-T Leu, W K Herber, R A F Dixon and P L Darke (1990). Crystallographic Analysis of a Complex between Human Immunodeficiency Virus Type 1 Protease and Acetyl-Pepstatin at 2.0 angstrom Resolution. J. Biol. Chem. 265: 14209-14219. [Medline info for 9539134]

GO terms associated with structures
Molecular functionRNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity, integrase activity, DNA binding
Biological processRNA-dependent DNA replication, DNA integration, DNA recombination, proteolysis and peptidolysis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu