Motion in HIV-1 protease [hivprot]

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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]

Structures
1HHP Conformation5 [ PartsList ]
1HIV Conformation4 [ PartsList ]
3HVP Conformation 2 [ PartsList ]
4HVP Conformation 1 [ PartsList ]
5HVP Conformation 3 [ PartsList ]

Description
Two large loop regions, that together comprise one quarter of the structure, move CA atoms ~ 7 Angstrom

Particular values describing motion
Creation Date = 19970822
Experimental Methods = x (Traditional x-ray)
Modification Date = 1998-06-27 22:06:24.000

References
Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134]
M Miller, J Schneider, B K Sathyanarayana, M V Toth, G R Marshall, L Clawson, L Selk, S B H Kent and A Wlodawer (1989). Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 angstrom Resolution. Science. 246: 1149-52. [Medline info for 9539134]
P M D Fitzgerald, B M McKeever, J F VanMiddlesworth, J P Springer, J C Heimbach, C-T Leu, W K Herber, R A F Dixon and P L Darke (1990). Crystallographic Analysis of a Complex between Human Immunodeficiency Virus Type 1 Protease and Acetyl-Pepstatin at 2.0 angstrom Resolution. J. Biol. Chem. 265: 14209-14219. [Medline info for 9539134]

GO terms associated with structures
Molecular functionRNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity, integrase activity, DNA binding, RNA binding
Biological processproteolysis and peptidolysis, RNA-dependent DNA replication, DNA integration, DNA recombination

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
4hvp [ ] 3hvp [ ] 99

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
579507-13693 HIV Prot upload [ A ] upload [ A ] 97
97211-12125 HIV Protease 1hvp [ A ] 9hvp [ A ] 99
455672-10258 hiv protease 4hvp [ A ] 3hvp [ A ] 99
081319-8883 hiv protease 1hvr [ A ] 1hhp [ A ] 99
349795-28305 HIV protease 1hvr [ A ] 1hhp [ A ] 99
09644-26029 HIV-1 1ajv [ A ] 1hvr [ A ] 99
717391-21293 HIV-1 Protease 1hiv [ A ] 1fb7 [ A ] 99
488412-20467 HIV-1 protease 1hhp [ A ] 7hvp [ A ] 97
479665-18269 HIV-1 Protease 7hvp [ A ] 1hsg [ A ] 99
469717-16884 HIV-1 Protease 7hvp [ A ] 1hsg [ A ] 99
406173-16013 HIV-1 protease upload [ A ] upload [ A ] 198
809419-31904 HIV-1 protease 16 fr 4hvp [ A ] 3hvp [ A ] 99
809518-32459 HIV-1 protease 24 fr 4hvp [ A ] 3hvp [ A ] 99
809317-31308 HIV-1 protease 8 fra 4hvp [ A ] 3hvp [ A ] 99
95317-10622 HIV-Protease I upload [ A ] upload [ A ] 99

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1ohrB-1hvpA Aspartylprotease 1ohr [ B ] 1hvp [ A ] 99
va1ohrB-1hvpB Aspartylprotease 1ohr [ B ] 1hvp [ B ] 99
va1ohrA-1hvpA Aspartylprotease 1ohr [ A ] 1hvp [ A ] 99
va1g35A-1hvpA Hiv-1 Protease 1g35 [ A ] 1hvp [ A ] 99
va1ajvB-1hvpA Hiv-1 Protease 1ajv [ B ] 1hvp [ A ] 99
va2upjB-1hvpB Hiv-1 Protease 2upj [ B ] 1hvp [ B ] 99
va2bpzB-1hvpA Hiv-1 Protease 2bpz [ B ] 1hvp [ A ] 99
va2bpwB-1hvpA Hiv-1 Protease 2bpw [ B ] 1hvp [ A ] 99
va1ajvA-1hvpA Hiv-1 Protease 1ajv [ A ] 1hvp [ A ] 99
va2bpzB-1hvpB Hiv-1 Protease 2bpz [ B ] 1hvp [ B ] 99
va1hsgB-1hvpA Hiv-1 Protease 1hsg [ B ] 1hvp [ A ] 99
va2bpvB-1hvpA Hiv-1 Protease 2bpv [ B ] 1hvp [ A ] 99
va2bpzA-1hvpA Hiv-1 Protease 2bpz [ A ] 1hvp [ A ] 99
va1ajxB-1hvpA Hiv-1 Protease 1ajx [ B ] 1hvp [ A ] 99
va1ajxA-1hvpA Hiv-1 Protease 1ajx [ A ] 1hvp [ A ] 99
va1hpxA-1hvpA Hiv-1 Protease 1hpx [ A ] 1hvp [ A ] 99
va1hpxA-1hvpB Hiv-1 Protease 1hpx [ A ] 1hvp [ B ] 99
va2bpxB-1hvpA Hiv-1 Protease 2bpx [ B ] 1hvp [ A ] 99
va1g35B-1hvpB Hiv-1 Protease 1g35 [ B ] 1hvp [ B ] 99
va1g35A-1hvpB Hiv-1 Protease 1g35 [ A ] 1hvp [ B ] 99
va7upjA-1hvpA Hiv-1 Protease 7upj [ A ] 1hvp [ A ] 99
va1ajvB-1hvpB Hiv-1 Protease 1ajv [ B ] 1hvp [ B ] 99
va2bpyB-1hvpA Hiv-1 Protease 2bpy [ B ] 1hvp [ A ] 99
va1ajxB-1hvpB Hiv-1 Protease 1ajx [ B ] 1hvp [ B ] 99
va1difB-1hvpB Hiv-1 Protease 1dif [ B ] 1hvp [ B ] 99
va2upjA-1hvpB Hiv-1 Protease 2upj [ A ] 1hvp [ B ] 99
va1hpxB-1hvpA Hiv-1 Protease 1hpx [ B ] 1hvp [ A ] 99
va1difA-1hvpA Hiv-1 Protease 1dif [ A ] 1hvp [ A ] 99
va1difA-1hvpB Hiv-1 Protease 1dif [ A ] 1hvp [ B ] 99
va1upjA-1hvpA Hiv-1 Protease 1upj [ A ] 1hvp [ A ] 99
va1gnoA-1hvpA Hiv-1 Protease 1gno [ A ] 1hvp [ A ] 99
va1hhpA-1hvpA Hiv-1 Protease (Bru Isolate) - 1hhp [ A ] 1hvp [ A ] 99
va1hihB-1hvpA Hiv-1 Protease (E.C. 3.4.23.-) 1hih [ B ] 1hvp [ A ] 99
va1hpvA-1hvpA Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ A ] 1hvp [ A ] 99
va1hpvB-1hvpA Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ B ] 1hvp [ A ] 99
va1hpvA-1hvpB Hiv-1 Protease (E.C. 3.4.23.-) 1hpv [ A ] 1hvp [ B ] 99
va1hosB-1hvpA Hiv-1 Protease Complex With Sb 1hos [ B ] 1hvp [ A ] 99
va1hosA-1hvpA Hiv-1 Protease Complex With Sb 1hos [ A ] 1hvp [ A ] 99
va1hosA-1hvpB Hiv-1 Protease Complex With Sb 1hos [ A ] 1hvp [ B ] 99
va1hvpB-3phvA HIV-1 Protease Complex With Su 1hvp [ B ] 3phv [ A ] 99
va1hvpA-2upjB HIV-1 Protease Complex With Su 1hvp [ A ] 2upj [ B ] 99
va1hvpB-7upjA HIV-1 Protease Complex With Su 1hvp [ B ] 7upj [ A ] 99
va1hvpB-2bpxA HIV-1 Protease Complex With Su 1hvp [ B ] 2bpx [ A ] 99
va1hvpB-1c70A HIV-1 Protease Complex With Su 1hvp [ B ] 1c70 [ A ] 99
va1hvpA-2bpyA HIV-1 Protease Complex With Su 1hvp [ A ] 2bpy [ A ] 99
va1hvpA-2bpvA HIV-1 Protease Complex With Su 1hvp [ A ] 2bpv [ A ] 99
va1hvpB-2bpwA HIV-1 Protease Complex With Su 1hvp [ B ] 2bpw [ A ] 99
va1hvpB-2bpvA HIV-1 Protease Complex With Su 1hvp [ B ] 2bpv [ A ] 99
va1hvpB-1hteB HIV-1 Protease Complex With Su 1hvp [ B ] 1hte [ B ] 99
va1hvpB-1hvjB HIV-1 Protease Complex With Su 1hvp [ B ] 1hvj [ B ] 99
va1hvpB-1hvkB HIV-1 Protease Complex With Su 1hvp [ B ] 1hvk [ B ] 99
va1hvpB-2bpxB HIV-1 Protease Complex With Su 1hvp [ B ] 2bpx [ B ] 99
va1hvpA-2upjA HIV-1 Protease Complex With Su 1hvp [ A ] 2upj [ A ] 99
va1hvpB-1hviB HIV-1 Protease Complex With Su 1hvp [ B ] 1hvi [ B ] 99
va1hvpA-1hvjA HIV-1 Protease Complex With Su 1hvp [ A ] 1hvj [ A ] 99
va1hvpB-1hvjA HIV-1 Protease Complex With Su 1hvp [ B ] 1hvj [ A ] 99
va1hvpB-1hviA HIV-1 Protease Complex With Su 1hvp [ B ] 1hvi [ A ] 99
va1hvpA-1gnoB HIV-1 Protease Complex With Su 1hvp [ A ] 1gno [ B ] 99
va1hvpA-1hvlA HIV-1 Protease Complex With Su 1hvp [ A ] 1hvl [ A ] 99
va1hvpB-1gnoB HIV-1 Protease Complex With Su 1hvp [ B ] 1gno [ B ] 99
va1hvpB-1htfA HIV-1 Protease Complex With Su 1hvp [ B ] 1htf [ A ] 99
va1hvpB-1gnoA HIV-1 Protease Complex With Su 1hvp [ B ] 1gno [ A ] 99
va1hvpB-1upjA HIV-1 Protease Complex With Su 1hvp [ B ] 1upj [ A ] 99
va1hvpB-1hosB HIV-1 Protease Complex With Su 1hvp [ B ] 1hos [ B ] 99
va1hvpB-1hpvB HIV-1 Protease Complex With Su 1hvp [ B ] 1hpv [ B ] 99
va1hvpB-1hbvB HIV-1 Protease Complex With Su 1hvp [ B ] 1hbv [ B ] 99
va1hvpA-3phvA HIV-1 Protease Complex With Su 1hvp [ A ] 3phv [ A ] 99
va1hvpB-1hhpA HIV-1 Protease Complex With Su 1hvp [ B ] 1hhp [ A ] 99
va1hvpA-1hteA HIV-1 Protease Complex With Su 1hvp [ A ] 1hte [ A ] 99
va1hvpB-1hteA HIV-1 Protease Complex With Su 1hvp [ B ] 1hte [ A ] 99
va1hvpA-1g2kA HIV-1 Protease Complex With Su 1hvp [ A ] 1g2k [ A ] 99
va1hvpA-1g35B HIV-1 Protease Complex With Su 1hvp [ A ] 1g35 [ B ] 99
va1hvpA-7upjB HIV-1 Protease Complex With Su 1hvp [ A ] 7upj [ B ] 99
va1hvpB-7upjB HIV-1 Protease Complex With Su 1hvp [ B ] 7upj [ B ] 99
va1hvpA-2bpxA HIV-1 Protease Complex With Su 1hvp [ A ] 2bpx [ A ] 99
va1hvpB-2bpwB HIV-1 Protease Complex With Su 1hvp [ B ] 2bpw [ B ] 99
va1hvpB-1ajvA HIV-1 Protease Complex With Su 1hvp [ B ] 1ajv [ A ] 99
va1hvpB-2bpyB HIV-1 Protease Complex With Su 1hvp [ B ] 2bpy [ B ] 99
va1hvpB-1htgB HIV-1 Protease Complex With Su 1hvp [ B ] 1htg [ B ] 99
va1hvpB-1hsgB HIV-1 Protease Complex With Su 1hvp [ B ] 1hsg [ B ] 99
va1hvpB-2bpvB HIV-1 Protease Complex With Su 1hvp [ B ] 2bpv [ B ] 99
va1hvpB-2bpzA HIV-1 Protease Complex With Su 1hvp [ B ] 2bpz [ A ] 99
va1hvpA-2bpwA HIV-1 Protease Complex With Su 1hvp [ A ] 2bpw [ A ] 99
va1hvpB-1ajxA HIV-1 Protease Complex With Su 1hvp [ B ] 1ajx [ A ] 99
va1hvpB-2bpyA HIV-1 Protease Complex With Su 1hvp [ B ] 2bpy [ A ] 99
va1hvpA-1htgA HIV-1 Protease Complex With Su 1hvp [ A ] 1htg [ A ] 99
va1hvpB-1htgA HIV-1 Protease Complex With Su 1hvp [ B ] 1htg [ A ] 99
va1hvpA-1hsgA HIV-1 Protease Complex With Su 1hvp [ A ] 1hsg [ A ] 99
va1hvpB-1hsgA HIV-1 Protease Complex With Su 1hvp [ B ] 1hsg [ A ] 99
va1hvpA-1difB HIV-1 Protease Complex With Su 1hvp [ A ] 1dif [ B ] 99
va1hvpB-1hvlB HIV-1 Protease Complex With Su 1hvp [ B ] 1hvl [ B ] 99
va1hvpB-1hihB HIV-1 Protease Complex With Su 1hvp [ B ] 1hih [ B ] 99
va1hvpA-1hihA HIV-1 Protease Complex With Su 1hvp [ A ] 1hih [ A ] 99
va1hvpB-1hihA HIV-1 Protease Complex With Su 1hvp [ B ] 1hih [ A ] 99
va1hvpA-1hvkA HIV-1 Protease Complex With Su 1hvp [ A ] 1hvk [ A ] 99
va1hvpB-1hpxB HIV-1 Protease Complex With Su 1hvp [ B ] 1hpx [ B ] 99
va1hvpB-1hvkA HIV-1 Protease Complex With Su 1hvp [ B ] 1hvk [ A ] 99
va1hvpB-1ohrA HIV-1 Protease Complex With Su 1hvp [ B ] 1ohr [ A ] 99
va1hvpA-1hviA HIV-1 Protease Complex With Su 1hvp [ A ] 1hvi [ A ] 99
va1hvpB-1htfB HIV-1 Protease Complex With Su 1hvp [ B ] 1htf [ B ] 99
va1hvpA-1htfA HIV-1 Protease Complex With Su 1hvp [ A ] 1htf [ A ] 99
va1hvpB-1hpsB HIV-1 Protease Complex With Su 1hvp [ B ] 1hps [ B ] 99
va1hvpB-1hvlA HIV-1 Protease Complex With Su 1hvp [ B ] 1hvl [ A ] 99
va1hvpA-1hbvA HIV-1 Protease Complex With Su 1hvp [ A ] 1hbv [ A ] 99
va1hvpB-1hbvA HIV-1 Protease Complex With Su 1hvp [ B ] 1hbv [ A ] 99
va1hteB-1hvpA Hiv-1 Protease Complexed With 1hte [ B ] 1hvp [ A ] 99
va1hvkB-1hvpA Hiv-1 Protease Complexed With 1hvk [ B ] 1hvp [ A ] 99
va1hpsB-1hvpA Hiv-1 Protease Complexed With 1hps [ B ] 1hvp [ A ] 99
va1hpsA-1hvpB Hiv-1 Protease Complexed With 1hps [ A ] 1hvp [ B ] 99
va1hbvB-1hvpA Hiv-1 Protease Complexed With 1hbv [ B ] 1hvp [ A ] 99
va1htgB-1hvpA Hiv-1 Protease Complexed With 1htg [ B ] 1hvp [ A ] 99
va1hvjB-1hvpA Hiv-1 Protease Complexed With 1hvj [ B ] 1hvp [ A ] 99
va1hvlB-1hvpA Hiv-1 Protease Complexed With 1hvl [ B ] 1hvp [ A ] 99
va1hviB-1hvpA Hiv-1 Protease Complexed With 1hvi [ B ] 1hvp [ A ] 99
va1htfB-1hvpA Hiv-1 Protease Complexed With 1htf [ B ] 1hvp [ A ] 99
va1hpsA-1hvpA Hiv-1 Protease Complexed With 1hps [ A ] 1hvp [ A ] 99
va1c70B-1hvpA Protease 1c70 [ B ] 1hvp [ A ] 99
va1c70B-1hvpB Protease 1c70 [ B ] 1hvp [ B ] 99
va1c70A-1hvpA Protease 1c70 [ A ] 1hvp [ A ] 99
va1g2kB-1hvpA Protease Retropepsin 1g2k [ B ] 1hvp [ A ] 99
va1g2kB-1hvpB Protease Retropepsin 1g2k [ B ] 1hvp [ B ] 99
va1g2kA-1hvpB Protease Retropepsin 1g2k [ A ] 1hvp [ B ] 99

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu