Motion in HIV-1 protease [hivprot]
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Classification Known Fragment Motion, Hinge Mechanism [F-h-2]
Structures 1HHP Conformation5 [ PartsList ] 1HIV Conformation4 [ PartsList ] 3HVP Conformation 2 [ PartsList ] 4HVP Conformation 1 [ PartsList ] 5HVP Conformation 3 [ PartsList ]
Description Two large loop regions, that together comprise one quarter of the structure, move CA atoms ~ 7 Angstrom
Particular values describing motion Creation Date = 19970822 Experimental Methods = x (Traditional x-ray) Modification Date = 1998-06-27 22:06:24.000
References Anonymous (1995). Views of HIV proteins for drug designers. Nat. 374:578. [Medline info for 9539134] M Miller, J Schneider, B K Sathyanarayana, M V Toth, G R Marshall, L Clawson, L Selk, S B H Kent and A Wlodawer (1989). Structure of Complex of Synthetic HIV-1 Protease with a Substrate-Based Inhibitor at 2.3 angstrom Resolution. Science. 246: 1149-52. [Medline info for 9539134] P M D Fitzgerald, B M McKeever, J F VanMiddlesworth, J P Springer, J C Heimbach, C-T Leu, W K Herber, R A F Dixon and P L Darke (1990). Crystallographic Analysis of a Complex between Human Immunodeficiency Virus Type 1 Protease and Acetyl-Pepstatin at 2.0 angstrom Resolution. J. Biol. Chem. 265: 14209-14219. [Medline info for 9539134]
GO terms associated with structures Molecular function RNA binding, RNA-directed DNA polymerase activity, aspartic-type endopeptidase activity, zinc ion binding, nucleic acid binding, ribonuclease H activity, integrase activity, DNA binding Biological process RNA-dependent DNA replication, DNA integration, DNA recombination, proteolysis and peptidolysis
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu