Motion in S. aureus alpha-Hemolysin [hemolysin]

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Classification [D-f-2]

Structures 1LKF 7AHL [ PartsList ]

Description a-Hemolysin forms a heptamer channel with long extended strands joining at the core. The soluble form of a related protein, LukF, has this domain folded up and retracted, and is thought to be analogous to the soluble, monomeric form of hemolysin.

References R Olson, H Nariya, K Yokota, Y Kamio, E Gouaux (1999). Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel. Nat Struct Biol, 6:134-40 [Medline info for 10048924] L Song, M R Hobaugh, C Shustak, S Cheley, H Bayley, J E Gouaux (1996). Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science, 274:1859-66 [Medline info for 8943190]

GO terms associated with structures Cellular component extracellular region Biological process hemolysis, pathogenesis

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu