Motion in Heparin Cofactor II [hc2]

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Classification [S-a-2]

Structures 1JMJ 1JMO

Description Similar to antithrombin (AT). Movement in subunit of HCII dimer includes the expulsion of the reactive center loop, closure of beta -sheet A, and the consequent release of the acidic tail. Multistep allosteric mechanism implied by conformational changes.

References Trevor P Baglin, Robin W Carrell, Frank C Church, Charles T Esmon, James A Huntington (2002). Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism. Proc Natl Acad Sci U S A, 99:11079-84 [Medline info for 12169660]

GO terms associated with structures Molecular function chymotrypsin activity, trypsin activity, calcium ion binding, serine-type endopeptidase inhibitor activity, thrombin activity Cellular component extracellular region Biological process proteolysis and peptidolysis, blood coagulation

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu