Motion in GroES mobile loop [groesloop]

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Classification Known Fragment Motion, Unclassifiable [F-?-2]

Structures
1AON Subunit by X-ray [ PartsList ]
1EGS Loop by TrNOE NMR

Description
The 18-residue GroES mobile loop undogoes conformational fluctuations similar to that of a random coil polypeptide with a slight bias toward formation of a hairpin near the center of the loop. The movie shows three conformations that have been trapped by intermolecular interactions: lattice packing in the GroES crystal (structure not yet in the PDB), GroEL binding by a synthetic GroES peptide, and GroEL binding in the native complex.

Particular values describing motion
Creation Date = 1999-05-18 10:32:37.000
Experimental Methods = xn (Traditional X-ray and NMR)
Modification Date = 1999-05-24 16:48:09.000

References
Hunt et al., Nature 1996 Jan 4;379(6560):37-45; GroES crystal structure with mobile loop trapped in crystal lattice [Medline info for 8538739]
Landry et al., Nature 1993 Jul 15;364(6434):255-8; GroES mobile loop identified by NMR [Medline info for 8100614]
Landry et al., Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11622-7; TrNOE NMR structure of GroEL-bound GroES Mobile Loop Peptide [Medline info for 8876186]
Xu et al., Nature 1997 Aug 21;388(6644):741-50; GroEL-GroES-(ADP)7 crystal structure [Medline info for 9285585]

Data and Graphics
Animated GIF GroES Mobile Loop Movie

GO terms associated with structures
Molecular functionprotein binding, ATP binding
Biological processcellular protein metabolism, protein folding

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
GroES loop 1AON [ ] 1EGS [ ] 97



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu