Motion in Glur2 ligand-binding core [glur2]
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Classification [D-h-2]
Structures 1FTO from rat; open 1FTM closed
Description This motion is essentially identical to the glutamine binding protein, whose structures have been solved in E. coli.
References G Q Chen, Y Sun, R Jin, E Gouaux (1998). Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct. Protein Sci, 7:2623-30 [Medline info for 9865957] N Armstrong, E Gouaux (2000). Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28:165-81 [Medline info for 11086992]
GO terms associated with structures Molecular function transporter activity, ion channel activity, glutamate-gated ion channel activity, receptor activity, potassium channel activity, ionotropic glutamate receptor activity Cellular component membrane Biological process transport, ion transport, potassium ion transport
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu