Motion in Glycerol Kinase [gk]

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Classification Known Domain Motion, Shear Mechanism [D-s-2]

Description
Expected to be similar to hexokinase and actin based on structural similarity. However, domain repositioning is accurately described by rigid body motion rather than rearrangement of secondary struture elements. The motion also appears to be directly related to allosteric regulation by the regulator Fructose 1,6-bisphosphate which is a non-competitive inhibitor.

Particular values describing motion
Creation Date = 1998-10-23 09:58:31.000
Experimental Methods = x (Traditional x-ray)
Maximum Rotation (degrees) = 6.2
Maximum Translation (A) = 0.2
Number of hinges = 1
Modification Date = 1998-11-06 22:13:01.000

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Glycerol Kinase upload [ ] upload [ ] 502



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu