Motion in Folylpolyglutamate Synthetase [fpgs]

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Classification [D-h-2]

Structures
1JBV
1JBW

Description
From the abstract to Sun et al. (J Mol Biol. 2001 310:1067-78): ". . .binding of folate as the second substrate triggers a large conformational change that activates FPGS and allows the enzyme to adopt a form that is then able to bind the third substrate, L-glutamate, and effect the addition of a polyglutamate tail to the folate."

GO terms associated with structures
Molecular functionligase activity, tetrahydrofolylpolyglutamate synthase activity, ATP binding
Biological processfolic acid and derivative biosynthesis, biosynthesis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Folylpolyglutamate Synthetase 1jbv [ A ] 1jbw [ A ] 427



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu