Motion in FecA transporter [feca]

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Classification [F-h-2]

Structures
1kmo unliganded
1kmp with ferric citrate

Description
Integral membrane transporter from E. coli. Solved by A Ferguson et al. in Deisenhofer lab (Science 295:1715-9). From the abstract: "Binding of ferric citrate triggers a conformational change of the extracellular loops that close the external pocket of FecA. Ligand-induced allosteric transitions are propagated through the outer membrane by the plug domain, signaling the occupancy of the receptor in the periplasm."

References
Ferguson AD, Chakraborty R, Smith BS, Esser L, van der Helm D, Deisenhofer J (2002). Structural basis of gating by the outer membrane transporter FecA. Science 295:1715-9. [Medline info for 11872840]

GO terms associated with structures
Molecular functioniron ion binding, receptor activity, siderophore-iron transporter activity, transporter activity
Cellular componentmembrane, outer membrane
Biological processsiderophore transport, transport, nutrient import

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
FecA upload [ A ] upload [ A ] 633



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu