Motion in Various Kinases (Tyr, Ser, Thr) [erk2]

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Classification Known Domain Motion, Hinge Mechanism [D-h-2]

Structures
1ERK MAP Kinase [ PartsList ]
1IRK Domain from insulin receptortyrosine kinase [ PartsList ]
1KOB twitchin Kinase [ PartsList ]

Description
Has a similar motion to cAMP-dependent protein kinase (pka) but only solved in one conformation.
According to Hubbard et al. paper, N-terminal domain of tyrosine kinase (IRK) is rotated 26 degrees and translated 0.8 A relative to closed form of pka and 19 and 2.1 relative to open form.
MAP Kinase and twitchin adopt more open conformations with rotations relative to the open form of pka of 17 and 30 degrees, respectively.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19971214

References
F Zhang, A Strand, D Robbins, M Cobb and E J Goldsmith (1994). Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature. 367: 704-710. [Medline info for 94150699]
Hubbard SR; Wei L; Ellis L; Hendrickson WA (1994). Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372: 746-54. [Medline info for 95089813]
Morgan DO, De Bondt HL (1994). Protein kinase regulation: insights from crystal structure analysis. Curr Opin Cell Biol. 6(2):239-246. [Medline info for 94296697]

GO terms associated with structures
Molecular functionATP binding, protein kinase activity, protein-tyrosine kinase activity, protein serine/threonine kinase activity, transmembrane receptor protein tyrosine kinase activity, MAP kinase activity, epidermal growth factor receptor activity
Cellular componentmembrane
Biological processtransmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
MAPK ERK 1erk [ A ] 2erk [ A ] 363

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
22046-523 CDK2 upload [ A ] upload [ A ] 298
54880-825 CDK2 1hcl [ ] 1fin [ ] 298
82167-27134 CDK2 1hcl [ ] 1fin [ ] 298
357733-24019 CDK2 1fin [ A ] 1hck [ A ] 298
87645-5838 Creatine Kinase 2crk [ A ] 1crk [ A ] 380
25349-1061 Cyclin Dependant Kin upload [ A ] upload [ A ] 298
50119-516 Cyclin Dependent Kin upload [ A ] upload [ A ] 297
424049-23857 cyclin-dependent kinase 2 1hcl [ A ] 1fin [ A ] 298
205116-18931 ERK upload [ A ] upload [ A ] 351
784725-32162 human CDK2 1hck [ A ] 1g5s [ A ] 298


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu