Motion in Erythropoietin Receptor [epr]

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Classification Suspected Subunit Motion, Not Involving Allostery [S-n-1]

Structures 1ERN Conformation 1

Description Crystallographic evidence suggests that the erythropoietin receptor signals via a conformational change of the dimer.

Particular values describing motion Creation Date = 1999-07-27 14:20:46.000 Experimental Methods = x (Traditional x-ray) Modification Date = 1999-07-27 14:23:50.000

References Science 1999 Feb 12;283(5404):987-90 Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Livnah O, Stura EA, Middleton SA, Johnson DL, Jolliffe LK, Wilson IA [Medline info for 9974392]

Data and Graphics Science Paper Full article in Science

GO terms associated with structures Molecular function transmembrane receptor activity, hematopoietin/interferon-class (D200-domain) cytokine receptor activity Cellular component membrane, integral to membrane

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu