Motion in Erythropoietin (binding receptor) [epo]

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Classification [S-a-2]

Structures
1BUY
1EER

Description
Motion is detected in comparison of the NMR structure of unbound erythropoietin and the x-ray structure of the complex with the receptor.

References
J C Cheetham, D M Smith, K H Aoki, J L Stevenson, T J Hoeffel, R S Syed, J Egrie, T S Harvey (1998). NMR structure of human erythropoietin and a comparison with its receptor bound conformation. Nat Struct Biol, 5:861-6 [Medline info for 9783743]
R S Syed, S W Reid, C Li, J C Cheetham, K H Aoki, B Liu, H Zhan, T D Osslund, A J Chirino, J Zhang, J Finer-Moore, S Elliott, K Sitney, B A Katz, D J Matthews, J J Wendoloski, J Egrie, R M Stroud (1998). Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395:511-6 [Medline info for 9774108]

GO terms associated with structures
Molecular functionhematopoietin/interferon-class (D200-domain) cytokine receptor activity, erythropoietin receptor binding, hormone activity, transmembrane receptor activity
Cellular componentmembrane, integral to membrane, extracellular region

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
Human Erythropoietin 1buy [ A ] 1eer [ A ] 166



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu