Motion in Elongation Factor Tu (EF-Tu) [eftu]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures
1EFT Conformation 2 [ PartsList ]
1ETU Conformation 1 [ PartsList ]
1EXM Complex with GTP analogue (T. thermophilus)
1EFC Complex with GDP (E. coli)

Description
Internal loop movements similar to those in ras protein (below) lead to large domain rearragements (90 degree rotation, 40 Angstrom shifts) Structures of 2 conformations have been solved.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
H Berchtold, L Reshetnikova, C O A Reiser, N K Schirmer, M Sprinzl and R Hilgenfeld (1993). Crystal structure of active elongation factor Tu reveals major domain rearrangements. Nature. 365: 126-132. [Medline info for 93382498]
M Kjeldgaard, P Nissan, S Thirup and J Nyborg (1993). The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation. Structure. 1: 35-50. [Medline info for 94248863]

GO terms associated with structures
Molecular functiontranslation elongation factor activity, GTP binding
Biological processtranslational elongation, protein biosynthesis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
test movie of eftu 1etu [ A ] 1eft [ A ] 405

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
913097-29763 EF-Tu 1eft [ A ] 1tui [ A ] 405
367274-4116 EF-Tu 1eft [ A ] 1tui [ A ] 405
269406-31561 EF_TU GTP &tRNA upload [ A ] upload [ A ] 405
23666-32669 Elongation factor Tu upload [ A ] upload [ B ] 393
592512-28572 Elongation Factor Tu (EF-Tu) 1tui [ A ] 1eft [ A ] 405
209311-24507 tu 1ttt [ A ] 1efc [ A ] 393


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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu