Motion in Elongation Factor Tu (EF-Tu) [eftu]

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Classification Known Domain Motion, Unclassifiable Mechanism [D-?-2]

Structures 1EFT Conformation 2 [ PartsList ] 1ETU Conformation 1 [ PartsList ] 1EXM Complex with GTP analogue (T. thermophilus) 1EFC Complex with GDP (E. coli)

Description Internal loop movements similar to those in ras protein (below) lead to large domain rearragements (90 degree rotation, 40 Angstrom shifts) Structures of 2 conformations have been solved.

Particular values describing motion Experimental Methods = x (Traditional x-ray) Creation Date = 19970822 Modification Date = 19970822

References H Berchtold, L Reshetnikova, C O A Reiser, N K Schirmer, M Sprinzl and R Hilgenfeld (1993). Crystal structure of active elongation factor Tu reveals major domain rearrangements. Nature. 365: 126-132. [Medline info for 93382498] M Kjeldgaard, P Nissan, S Thirup and J Nyborg (1993). The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation. Structure. 1: 35-50. [Medline info for 94248863]

GO terms associated with structures Molecular function translation elongation factor activity, GTP binding Biological process protein biosynthesis, translational elongation

Morphs

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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu