Motion in Diphtheria Toxin (DT) [dt]
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Classification Known Domain Motion, Hinge Mechanism [D-h-2]
Structures 1DDT Conformation 1 [ PartsList ] 1MDT Conformation 2 [ PartsList ]
Description 1 interdomain linkage, 1 hinge, 180 degree rotation, motions up to 65 A. Comparison of monomer and dimer reveal one domain has moved to a more open conformation in the latter.
Particular values describing motion Experimental Methods = x (Traditional x-ray) Modification Date = 1999-08-14 17:02:13.000 Creation Date = 19970822
References M J Bennett, M P Schlunegger, and D Eisenberg (1995). 3D Domain swapping: A Mechanism for oligomer assembly. Prot. Sci 4:2455-2468. [Medline info for 96164377] M J Bennett, S Choe and D Eisenberg (1994). Domain swapping: entangling alliances between proteins. Proc Natl Acad Sci U S A. 91: 3127-3131. [Medline info for 94211815]
GO terms associated with structures Molecular function NAD+-diphthamide ADP-ribosyltransferase activity Cellular component extracellular region Biological process pathogenesis
Morphs
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Best representative Morph Morph name Structure #1 Structure #2 Residues [ ] [ ]
Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu