Motion in DnaK chaperone [dnak]

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Classification [D-h-2]

Structures
1DKX Monomer [ PartsList ]
1DKY Dimer [ PartsList ]
1DKZ Monomer [ PartsList ]

Description
Consists of alpha and beta domains; the former binds the substrate peptide. The alpha domain is rotated in 1DKY versus the other two structures. From Zhu et al. : "This domain is rotated in the molecules of a second crystal lattice, which suggests a model of conformation-dependent substrate binding that features a latch mechanism for maintaining long lifetime complexes."

References
X Zhu, X Zhao, W F Burkholder, A Gragerov, C M Ogata, M E Gottesman, W A Hendrickson (1996). Structural analysis of substrate binding by the molecular chaperone DnaK. Science, 272:1606-14 [Medline info for 8658133]

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
DnaK 1dkx [ A ] 1dky [ A ] 219



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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu