Motion in Dihydrofolate Reductase (DHFR) [dhfr]

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Classification Known Fragment Motion, Shear Mechanism [F-s-2]

Structures
4DFR Conformation 1 [ PartsList ]
5DFR Conformation 2 [ PartsList ]
1RX2 [ PartsList ]
1RX7 [ PartsList ]

Description
Small (~3 Angstrom) movement, shearing interface with hinges.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
C Bystroff and J Kraut (1991). Crystal Structure of Unliganded Escherichia coli Dihydrofolate Reductase Ligand-Induced Conformational Changes and Cooperativity in Binding. Biochemistry. 30: 2227-2239. [Medline info for 94087720]
Sawaya, M. R., Kraut, J.: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry 36 pp. 586 (1997) [Medline info for 9012674]

GO terms associated with structures
Molecular functiondihydrofolate reductase activity
Biological processnucleotide biosynthesis, glycine biosynthesis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu