Motion in Dihydrofolate Reductase (DHFR) [dhfr]

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Classification Known Fragment Motion, Shear Mechanism [F-s-2]

Structures
4DFR Conformation 1 [ PartsList ]
5DFR Conformation 2 [ PartsList ]
1RX2 [ PartsList ]
1RX7 [ PartsList ]

Description
Small (~3 Angstrom) movement, shearing interface with hinges.

Particular values describing motion
Experimental Methods = x (Traditional x-ray)
Creation Date = 19970822
Modification Date = 19970822

References
C Bystroff and J Kraut (1991). Crystal Structure of Unliganded Escherichia coli Dihydrofolate Reductase Ligand-Induced Conformational Changes and Cooperativity in Binding. Biochemistry. 30: 2227-2239. [Medline info for 94087720]
Sawaya, M. R., Kraut, J.: Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence. Biochemistry 36 pp. 586 (1997) [Medline info for 9012674]

GO terms associated with structures
Molecular functiondihydrofolate reductase activity
Biological processglycine biosynthesis, nucleotide biosynthesis

Morphs

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Best representative
Morph Morph name Structure #1 Structure #2 Residues
dfr 4dfr [ A ] 5dfr [ A ] 159

User-submitted morphs
Morph Morph name Structure #1 Structure #2 Residues
dhfr 4dfr [ ] 5dfr [ ] 159
97987-11835 Aspartate Transcarba 4dfr [ A ] 5dfr [ A ] 159
71549-28151 dhfr 1rx2 [ A ] 1rx7 [ A ] 159
002701-25579 DHFR 1ra9 [ A ] 1rx2 [ A ] 159
185004-19357 dhfr 1rx6 [ A ] 1ra2 [ A ] 159
476275-28781 DHFR: 3-6 1rx3 [ A ] 1rx6 [ A ] 159
00205-18035 dihydrofolate reduct 4dfr [ A ] 5dfr [ A ] 159
17297-19483 Dihydrofolate reduct upload [ A ] upload [ A ] 159
393453-24120 Dihydrofolate Reductase 1rx7 [ A ] 1rx2 [ A ] 159

Automatic morphs
Morph Morph name Structure #1 Structure #2 Residues
va1rg7A-1rd7B Dihydrofolate Reductase 1rg7 [ A ] 1rd7 [ B ] 159
va1rg7A-1ra9A Dihydrofolate Reductase 1rg7 [ A ] 1ra9 [ A ] 159
va1re7B-1rg7A Dihydrofolate Reductase 1re7 [ B ] 1rg7 [ A ] 159
va1rg7A-1ra8A Dihydrofolate Reductase 1rg7 [ A ] 1ra8 [ A ] 159
va1rg7A-1re7A Dihydrofolate Reductase 1rg7 [ A ] 1re7 [ A ] 159
va1ddsB-1rg7A Dihydrofolate Reductase 1dds [ B ] 1rg7 [ A ] 159
va1rg7A-2drcB Dihydrofolate Reductase 1rg7 [ A ] 2drc [ B ] 159
va1rg7A-1drbB Dihydrofolate Reductase 1rg7 [ A ] 1drb [ B ] 159
va1rg7A-1jolB Dihydrofolate Reductase 1rg7 [ A ] 1jol [ B ] 159
va1rg7A-1rb2B Dihydrofolate Reductase 1rg7 [ A ] 1rb2 [ B ] 159
va1rg7A-1draB Dihydrofolate Reductase 1rg7 [ A ] 1dra [ B ] 159
va1ra1A-1rg7A Dihydrofolate Reductase 1ra1 [ A ] 1rg7 [ A ] 159
va1rg7A-1rx5A Dihydrofolate Reductase 1rg7 [ A ] 1rx5 [ A ] 159
va1rg7A-1rd7A Dihydrofolate Reductase 1rg7 [ A ] 1rd7 [ A ] 159
va1rg7A-1rx6A Dihydrofolate Reductase 1rg7 [ A ] 1rx6 [ A ] 159
va1rg7A-1rb3A Dihydrofolate Reductase 1rg7 [ A ] 1rb3 [ A ] 159
va1ra2A-1rg7A Dihydrofolate Reductase 1ra2 [ A ] 1rg7 [ A ] 159
va1rf7A-1rg7A Dihydrofolate Reductase 1rf7 [ A ] 1rg7 [ A ] 159
va1ddrB-1rg7A Dihydrofolate Reductase 1ddr [ B ] 1rg7 [ A ] 159
va1rx1A-1rg7A Dihydrofolate Reductase 1rx1 [ A ] 1rg7 [ A ] 159
va1ra3A-1rg7A Dihydrofolate Reductase 1ra3 [ A ] 1rg7 [ A ] 159
va1rg7A-1dhiB Dihydrofolate Reductase 1rg7 [ A ] 1dhi [ B ] 159
va1rg7A-1rx2A Dihydrofolate Reductase 1rg7 [ A ] 1rx2 [ A ] 159
va1rg7A-1rb2A Dihydrofolate Reductase 1rg7 [ A ] 1rb2 [ A ] 159
va1rg7A-1rx7A Dihydrofolate Reductase 1rg7 [ A ] 1rx7 [ A ] 159
va1rg7A-1rx4A Dihydrofolate Reductase 1rg7 [ A ] 1rx4 [ A ] 159
va1rg7A-1tdrB Dihydrofolate Reductase 1rg7 [ A ] 1tdr [ B ] 159
va1rg7A-1rx9A Dihydrofolate Reductase 1rg7 [ A ] 1rx9 [ A ] 159
va1rg7A-1rb3B Dihydrofolate Reductase 1rg7 [ A ] 1rb3 [ B ] 159
va1rc4A-1rg7A Dihydrofolate Reductase 1rc4 [ A ] 1rg7 [ A ] 159
va1rg7A-1rx8A Dihydrofolate Reductase 1rg7 [ A ] 1rx8 [ A ] 159
va1dyhB-1rg7A Dihydrofolate Reductase (5,6,7 1dyh [ B ] 1rg7 [ A ] 159
va1dyiB-1rg7A Dihydrofolate Reductase (5,6,7 1dyi [ B ] 1rg7 [ A ] 159
va1dyjB-1rg7A Dihydrofolate Reductase (5,6,7 1dyj [ B ] 1rg7 [ A ] 159
va3drcB-1rg7A Dihydrofolate Reductase (Dhfr) 3drc [ B ] 1rg7 [ A ] 159

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Copyright 1995-2005 M. Gerstein, W. Krebs, S. Flores, N. Echols, and others
Email: Mark.Gerstein _at_ yale.edu